Article: Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.

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Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H
J. Neurosci., 2014

Table 3.

Properties of spontaneous extracellular field potential activities in thalamocortical slices

	WT mice	n	Scn1a^RH/+ mice	n
Spontaneous total activity	12 slices		17 slices
Frequency, cortex LIV	0.16 ± 0.08 min^-1	21	0.52 ± 0.08 min^-1^*	139
Frequency, thalamus VB	0.14 ± 0.11 min^-1	11	0.65 ± 0.13 min^-1^*	137
Nonsimultaneous activities (mV)
Amplitude, cortex LIV	0.26 ± 0.03		0.28 ± 0.04
Amplitude, thalamus VB	0.11 ± 0.01		0.09 ± 0.01
Simultaneous corticothalamic activities				86
Cortical generation (%)			29.1%
Thalamic generation (%)			32.6%
Unclear (%)			39.5%
Amplitude, cortex LIV (mV)			1.24 ± 0.06^**^{^,a}
Amplitude, thalamus VB (mV)			0.21 ± 0.05^**^{^,b}
Cortical HFOs 40-200 Hz		21		100
Absolute area (mV/ms)^{^c}	1.2 ± 0.4		30.6 ± 1.8^**
Normalized absolute area^{^d}	0.011 ± 0.005		0.058 ± 0.003^**
Cortical HFOs 200-600 Hz		21		100
Absolute area (mV/ms)^{^c}	0.51 ± 0.17		7.25 ± 0.47^**
Normalized absolute area^{^d}	0.003 ± 0.002		0.017 ± 0.001^**

Data are presented as means ± SEM. n, Number of analyzed activities.
↵^aIn comparison to layer IV non-simultaneous activities (Wilcoxon signed rank test).
↵^bIn comparison to thalamic VB non-simultaneous activities (Wilcoxon signed rank test).
↵^cNoise in absolute area subtracted from HFOs absolute area (see Materials and Methods).
↵^dHFO absolute area noise subtracted normalized to the absolute area of the spontaneous activity (0.1 Hz-1 kHz filtered; see Materials and Methods).
↵*p < 0.05 and
↵**p < 0.001, Mann-Whitney rank-sum test or, when noted, Wilcoxon signed rank test.

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source