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Article: Contributions of diverse excitatory and inhibitory neurons to recurrent network activity in cerebral cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Neske GT; Patrick SL; Connors BW
J. Neurosci., 2015


Table 3.

Properties of excitatory and inhibitory neurons in entorhinal cortexa

L2/3 Pyr (n = 29) L2/3 PV (n = 20) L2/3 SOM (NFS) (n = 6) L2/3 SOM (FS) (n = 9) L2/3 VIP (n = 21)
RMP (mV) -63.2 (2.9) -64.4 (2.9) -63.3 (3.8) -63.7 (4.5) -63.3 (3.6)
Rin (MΩ) 65.0 (26.7) 33.3 (16.3) 166.6 (99.6) 49.9 (21.6) 115.9 (32.4)
AP thresh (mV) -41.6 (5.7) -42.2 (5.4) -36.3 (4.6) -35.8 (5.1) -42.7 (4.0)
τm (ms) 16.8 (7.0) 4.0 (4.2) 22.9 (11.5) 6.0 (1.2) 10.1 (1.8)
AP half-width (ms) 0.77 (0.2) 0.24 (0.06) 0.50 (0.1) 0.40 (0.09) 0.50 (0.7)
Up firing rate (Hz) 6.4 (7.8) 21.3 (38.4) 1.0 (1.2) 35.5 (32.4) 0.06 (0.2)**
Up depolarization (mV) 5.5 (2.1) 7.3 (2.2) 4.5 (2.4) 10.1 (2.4) 2.2 (1.1)
σUp/σDown 13.7 (13.1) 9.7 (3.5) 5.7 (2.4) 23.9 (19.5) 3.2 (1.4)
GE (nS) 1.5 (1.1) 5.0 (3.8) NA* NA* 0.3 (0.1)
Gi (nS) 1.9 (1.4) 1.8 (2.6) NA* NA* 0.4 (0.6)

  • ↵aValues are mean (SD). RMP, Resting membrane potential; Rin, input resistance; AP thresh, action potential threshold; τm, membrane time constant; AP half-width, action potential half-width; σUp/σDown, normalized membrane potential SD during Up state; GE, excitatory conductance; GI, inhibitory conductance. n refers to the total number of cells studied.

  • ↵*NA, Not applicable; NFS SOM cells could not be distinguished from FS SOM cells using Cs-gluconate internal solution.

  • ↵**Only 2 of 13 VIP cells recorded in entorhinal cortex fired action potentials during the Up state.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 pyramidal cells resting membrane potential (mV) -63.2 -63.2 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 parvalbumin-expressing cells resting membrane potential (mV) -64.4 -64.4 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 non fast-spiking SOM-expressing cells resting membrane potential (mV) -63.3 -63.3 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 fast-spiking SOM-expressing cells resting membrane potential (mV) -63.7 -63.7 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layers 2/3 VIP-expressing cells resting membrane potential (mV) -63.3 -63.3 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 pyramidal cells input resistance (MΩ) 65.0 65.0 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 parvalbumin-expressing cells input resistance (MΩ) 33.3 33.3 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 non fast-spiking SOM-expressing cells input resistance (MΩ) 166.6 166.6 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 fast-spiking SOM-expressing cells input resistance (MΩ) 49.9 49.9 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layers 2/3 VIP-expressing cells input resistance (MΩ) 115.9 115.9 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 pyramidal cells spike threshold (mV) -41.6 -41.6 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 parvalbumin-expressing cells spike threshold (mV) -42.2 -42.2 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 non fast-spiking SOM-expressing cells spike threshold (mV) -36.3 -36.3 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 fast-spiking SOM-expressing cells spike threshold (mV) -35.8 -35.8 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layers 2/3 VIP-expressing cells spike threshold (mV) -42.7 -42.7 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 pyramidal cells membrane time constant (ms) 16.8 16.8 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 parvalbumin-expressing cells membrane time constant (ms) 4.0 4.0 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 non fast-spiking SOM-expressing cells membrane time constant (ms) 22.9 22.9 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 fast-spiking SOM-expressing cells membrane time constant (ms) 6.0 6.0 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layers 2/3 VIP-expressing cells membrane time constant (ms) 10.1 10.1 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 pyramidal cells spike half-width (ms) 0.77 0.77 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 parvalbumin-expressing cells spike half-width (ms) 0.24 0.24 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 non fast-spiking SOM-expressing cells spike half-width (ms) 0.5 0.5 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Medial entorhinal cortex layers 2/3 fast-spiking SOM-expressing cells spike half-width (ms) 0.4 0.4 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layers 2/3 VIP-expressing cells spike half-width (ms) 0.5 0.5 (ms) Data Table