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Article: Electrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in rats.

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Moraes DJ; da Silva MP; Bonagamba LG; Mecawi AS; Zoccal DB; Antunes-Rodrigues J; Varanda WA; Machado BH
J. Neurosci., 2013


Table 1.

Average values of electrophysiological properties of nonmodulated and all respiratory-modulated RVLM presympathetic neurons recorded from control and CIH rats

Control CIH
Group I (n = 9) Group II (n = 12) Group III (n = 12) Group IV (n = 12) Group I (n = 10) Group II (n = 12) Group III (n = 14) Group IV (n = 10)
Capacitance (pF) 39 ± 1.9 36 ± 1.7 40 ± 1.8 42 ± 1.8 40 ± 3.6 41.5 ± 2.8 38 ± 2.7 40 ± 1.2
Frequency (Hz) 6 ± 1.1 22 ± 3* 13 ± 2 8 ± 1.9 6.4 ± 2.2 20 ± 2.4 15 ± 3.1 9 ± 2
RMP (mV) -53 ± 2.2 -51 ± 2.3 -52 ± 3.2 -54 ± 3.4 -52 ± 4 -50 ± 2 -53 ± 2.1 -53 ± 2
Ri (MΩ) 335 ± 1.1** 162 ± 6.5# 245 ± 5## 515 ± 9 348 ± 8 159 ± 7 259 ± 5 509 ± 16.6
Excitability (spikes) 46 ± 6** 90 ± 8.7+ 61 ± 7 64 ± 6 49 ± 6 95 ± 7.7 59 ± 6.7 74 ± 5
AHP (mV) 7 ± 1.1### 3 ± 0.6 3.3 ± 0.7 6 ± 1.3 7.2 ± 2.2 2.8 ± 0.9 3 ± 0.9 6.2 ± 2.3

  • Excitability: values in response to injection of 100 pA of positive current.

  • ↵*p < 0.05 different in relation to groups I, III, and IV from control rats;

  • ↵**p < 0.001 different in relation to the groups II, III, and IV from control rats;

  • ↵#p < 0.001 different in relation to the groups III and IV from control rats;

  • ↵##p < 0.001 different in relation to the group IV from control rats;

  • ↵###p < 0.05 different in relation to the groups II and III from control rats;

  • ↵+p < 0.05 different in relation to the group III from control rats. CIH produced no changes in the electrophysiological properties of the 4 groups of RVLM presympathetic neurons characterized, and the differences among the groups in CIH were also similar to those observed in neurons from control rats.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other rostral ventrolateral medulla presympathetic catecholaminergic spinally projecting C1 neurons firing frequency (Hz) 6.0 ± 1.1 (9) 6.0 (Hz) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-modulated VGLUT-expressing neurons firing frequency (Hz) 22.0 ± 3.0 (12) 22.0 (Hz) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive postinspiratory-modulated VGLUT-expressing neurons firing frequency (Hz) 13.0 ± 2.0 (12) 13.0 (Hz) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-inhibited VGLUT-expressing neurons firing frequency (Hz) 8.0 ± 1.9 (12) 8.0 (Hz) Data Table
Other rostral ventrolateral medulla presympathetic catecholaminergic spinally projecting C1 neurons cell capacitance (pF) 39.0 ± 1.9 (9) 39.0 (pF) Data Table
Other rostral ventrolateral medulla presympathetic catecholaminergic spinally projecting C1 neurons resting membrane potential (mV) -53.0 ± 2.2 (9) -53.0 (mV) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-modulated VGLUT-expressing neurons resting membrane potential (mV) -51.0 ± 2.3 (12) -51.0 (mV) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive postinspiratory-modulated VGLUT-expressing neurons resting membrane potential (mV) -52.0 ± 3.2 (12) -52.0 (mV) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-inhibited VGLUT-expressing neurons resting membrane potential (mV) -54.0 ± 3.4 (12) -54.0 (mV) Data Table
Other rostral ventrolateral medulla presympathetic catecholaminergic spinally projecting C1 neurons input resistance (MΩ) 335.0 ± 1.1 (9) 335.0 (MΩ) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-modulated VGLUT-expressing neurons cell capacitance (pF) 36.0 ± 1.7 (12) 36.0 (pF) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-modulated VGLUT-expressing neurons input resistance (MΩ) 162.0 ± 6.5 (12) 162.0 (MΩ) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive postinspiratory-modulated VGLUT-expressing neurons input resistance (MΩ) 245.0 ± 5.0 (12) 245.0 (MΩ) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-inhibited VGLUT-expressing neurons input resistance (MΩ) 515.0 ± 9.0 (12) 515.0 (MΩ) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive postinspiratory-modulated VGLUT-expressing neurons cell capacitance (pF) 40.0 ± 1.8 (12) 40.0 (pF) Data Table
Other rostral ventrolateral medulla presympathetic catecholaminergic spinally projecting C1 neurons AHP amplitude (mV) 7.0 ± 1.1 (9) 7.0 (mV) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-modulated VGLUT-expressing neurons AHP amplitude (mV) 3.0 ± 0.6 (12) 3.0 (mV) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive postinspiratory-modulated VGLUT-expressing neurons AHP amplitude (mV) 3.3 ± 0.7 (12) 3.3 (mV) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-inhibited VGLUT-expressing neurons cell capacitance (pF) 42.0 ± 1.8 (12) 42.0 (pF) Data Table
Other rostral ventrolateral medulla presympathetic tyrosine hydroxylase-imunoreactive inspiratory-inhibited VGLUT-expressing neurons AHP amplitude (mV) 6.0 ± 1.3 (12) 6.0 (mV) Data Table