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Article: Neural precursor lineages specify distinct neocortical pyramidal neuron types.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Tyler WA; Medalla M; Guillamon-Vivancos T; Luebke JI; Haydar TF
J. Neurosci., 2015


Table 1.

Electrophysiological characteristics of fate-mapped neocortical neurons

Mean non-Tbr2 SD SEM Mean Tbr2 SD SEM p value
Vr (mV) -69.5 5.3 1.1 -66.2 5.8 1.2 0.049*
Rn (MOhm) 106.6 36.7 7.6 150.2 65.1 13.0 0.006*
Tau (ms) 16.4 6.2 1.3 18.7 8.6 1.7 0.292
Rheobase (pA) 205.0 63.9 13.3 141.2 58.2 11.9 0.0008*
Threshold (mV) -32.9 3.7 0.8 -36.1 4.7 0.9 0.012*
Amp (pA) 81.3 8.0 1.7 82.4 9.1 1.8 0.667
Duration at 1/2 (ms) 2.2 0.7 0.1 2.1 0.5 0.1 0.676
Sag (mV) 1.2 0.8 0.2 2.5 2.2 0.4 0.007*
RD (mV) 1.2 0.8 0.2 2.2 1.7 0.3 0.009*
Hump (mV) 2.1 1.3 0.3 2.2 2.2 0.4 0.803
AHP (mV) -12.7 2.5 0.5 -11.5 4.4 0.9 0.231
fAHP (mV) -4.8 2.5 0.5 -5.3 2.6 0.5 0.517
DAP (mV) 0.4 1.0 0.2 0.5 0.9 0.2 0.602
mAHP (mV) -7.8 1.9 0.4 -6.7 2.1 0.4 0.054*
tAHP (ms) 42.5 10.6 2.2 41.4 11.2 2.2 0.707
Frequency @ steady state near rheobase 6.94 4.9 1.0 6.88 6.6 1.3 0.975
Frequency @ steady state 200pA step 4.6 4.4 0.9 10.1 6.3 1.3 0.0012*
Increase in FF per 50 pA current step 0.05 0.02 0.01 0.08 0.03 0.01 0.002*
TFS (time to 1st spike, ms) 46.8 31.9 7.5 43 29 6.2 0.689
ISI 1 (ms) 82.4 54.6 12.8 78.4 51.2 10.9 0.810
ISI 2 (ms) 108.4 60.6 14.3 99.7 52.9 11.3 0.627
ISI 3 (ms) 115 71.9 16.9 103.3 51.9 11.1 0.544
FFA initial (%) 27.8 20.6 4.9 26.2 21.7 4.6 0.812
FFA late (%) 40.7 18.1 4.5 38.8 20.1 4.3 0.763
SEPSC
    Freq (Hz) 6.7 2.4 0.5 6.4 2.5 0.6 0.696
    Amp (pA) 16.6 4.0 0.9 20.5 7.2 1.7 0.044*
    Rise (ms) 1.8 0.4 0.1 1.6 0.3 0.1 0.185
    Half-width (ms) 8.5 0.8 0.2 9.3 1.2 0.3 0.015*
    Decay (ms) 5.9 0.6 0.1 7.1 1.2 0.3 0.001*
    Area (pAms) -174.2 48.8 10.9 -255.9 114.4 26.2 0.008*
  • *Denotes statistical significance.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell input resistance 106.6 106.6 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell ADP amplitude (mV) 0.5 0.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell medium AHP amplitude (mV) -7.8 7.8 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell medium AHP amplitude (mV) -6.7 6.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell AHP duration (ms) 42.5 42.5 (ms) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell AHP duration (ms) 41.4 41.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell firing frequency 6.94 6.94 (Hz) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell firing frequency 6.88 6.88 (Hz) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell input resistance 150.2 150.2 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell membrane time constant (ms) 16.4 16.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell resting membrane potential (mV) -69.5 -69.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell membrane time constant (ms) 18.7 18.7 (ms) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell rheobase (pA) 205.0 205.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell rheobase (pA) 141.2 141.2 (pA) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell spike threshold (mV) -32.9 -32.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell spike threshold (mV) -36.1 -36.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell spike amplitude (pA) 81.3 -- Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell spike amplitude (pA) 82.4 -- Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell resting membrane potential (mV) -66.2 -66.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell spike half-width (ms) 2.2 2.2 (ms) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell spike half-width (ms) 2.1 2.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell sag amplitude (mV) 1.2 1.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell sag amplitude (mV) 2.5 2.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell AHP amplitude (mV) -12.7 12.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell AHP amplitude (mV) -11.5 11.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell fast AHP amplitude (mV) -4.8 4.8 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 Tbr2 expressing pyramidal cell fast AHP amplitude (mV) -5.3 5.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 dorsal frontal cortex layer 2/3 non-Tbr2 expressing pyramidal cell ADP amplitude (mV) 0.4 0.4 (mV) Data Table