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Article: Estrous cycle plasticity in the hyperpolarization-activated current ih is mediated by circulating 17β-estradiol in preoptic area kisspeptin neurons.

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Piet R; Boehm U; Herbison AE
J. Neurosci., 2013


Table 1.

Basic electrophysiological properties of RP3V kisspeptin neurons

Resting membrane potential (mV)a Input resistance (GΩ)b Membrane time constant (ms)c Membrane capacitance (pF)d AP overshoot (mV)e AP half-duration (ms)f Rheobase (pA)g
OVX (n = 21 neurons, 6 mice) -44.57 ± 1.12 1.49 ± 0.08 0.28 ± 0.02 16.75 ± 0.81 24.68 ± 1.19 0.91 ± 0.03 8.33 ± 0.80
Diestrus (n = 21 neurons, 5 mice) -47.95 ± 1.82 1.25 ± 0.09† 0.36 ± 0.04 22.58 ± 1.48** 26.91 ± 1.91 0.82 ± 0.02* 8.81 ± 0.84
Proestrus (n = 19 neurons, 5 mice) -46.39 ± 1.06 0.92 ± 0.08‡ 0.26 ± 0.02 19.40 ± 0.92 21.61 ± 1.76 0.78 ± 0.02** 9.47 ± 1.20

  • Statistical comparisons were performed using one-way ANOVA and Newman-Keuls post-tests.

  • ↵ap = 0.23.

  • ↵bF(2,58) = 11.47, p = 0.0001; †p < 0.05, OVX versus diestrus, and p < 0.01, diestrus versus proestrus; ‡p < 0.001, OVX versus proestrus.

  • ↵cF(2,57) = 3.244, p = 0.046, post-tests not significant.

  • ↵dF(2,57) = 7.084, p = 0.002; **p < 0.01, OVX versus diestrus.

  • ↵ep = 0.09.

  • ↵fF(2,58) = 6.456, p = 0.003; *p < 0.05, OVX versus diestrus; **p < 0.01, OVX versus proestrus.

  • ↵gp = 0.70.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice resting membrane potential (mV) -47.95 ± 1.82 (21) -47.95 (mV) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice input resistance (GΩ) 1.25 ± 0.09 (21) 1250.0 (MΩ) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice membrane time constant (ms) 0.36 ± 0.04 (21) 0.36 (ms) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice cell capacitance (pF) 22.58 ± 1.48 (21) 22.58 (pF) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice spike peak (mV) 26.91 ± 1.91 (21) 26.91 (mV) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice spike width (ms) 0.82 ± 0.02 (21) 0.82 (ms) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from diestrus mice rheobase (pA) 8.81 ± 0.84 (21) 8.81 (pA) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice resting membrane potential (mV) -46.39 ± 1.06 (19) -46.39 (mV) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice input resistance (GΩ) 0.92 ± 0.08 (19) 920.0 (MΩ) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice resting membrane potential (mV) -44.57 ± 1.12 (21) -44.57 (mV) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice membrane time constant (ms) 0.26 ± 0.02 (19) 0.26 (ms) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice cell capacitance (pF) 19.4 ± 0.92 (19) 19.4 (pF) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice spike peak (mV) 21.61 ± 1.76 (19) 21.61 (mV) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice spike width (ms) 0.78 ± 0.02 (19) 0.78 (ms) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from proestrus mice rheobase (pA) 9.47 ± 1.2 (19) 9.47 (pA) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice input resistance (GΩ) 1.49 ± 0.08 (21) 1490.0 (MΩ) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice membrane time constant (ms) 0.28 ± 0.02 (21) 0.28 (ms) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice cell capacitance (pF) 16.75 ± 0.81 (21) 16.75 (pF) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice spike peak (mV) 24.68 ± 1.19 (21) 24.68 (mV) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice spike width (ms) 0.91 ± 0.03 (21) 0.91 (ms) Data Table
Other rostral periventricular region of the third ventricle kisspeptin expressing neurons from ovariectomized mice rheobase (pA) 8.33 ± 0.8 (21) 8.33 (pA) Data Table