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Article: Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus.

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Shikanai H; Yoshida T; Konno K; Yamasaki M; Izumi T; Ohmura Y; Watanabe M; Yoshioka M
J. Neurosci., 2012


Table 2.

Analysis of membrane potential parameters

Parameter 5-HT neuron (n = 43) 5-HT/GAD67 neuron (n = 10) GAD67 neuron (n = 4)
Resting membrane potential (mV) -61.82 ± 1.67 -64.91 ± 4.14 -52.13 ± 17.17
Threshold (mV) -27.36 ± 1.05 -31.06 ± 1.50 -24.06 ± 7.04
Action potential amplitude (mV) 70.37 ± 2.65 68.94 ± 3.94 45.30 ± 5.59*
Action potential duration (ms) 2.22 ± 0.12 1.98 ± 0.24 1.78 ± 0.22
Afterhyperpolarization (mV) -25.66 ± 1.22 -24.14 ± 1.31 -29.00 ± 7.91
  • Significantly lower amplitudes of action potentials are observed in GAD67 neurons among the three neuronal groups (F(2,54) = 4.372;

  • *p < 0.05). No significant differences were found in the action potential duration [F(2,54) = 0.982, not significant (n.s.)], afterhyperpolarization (F(2,54) = 0.856, n.s.), or resting membrane potential (F(2,54) = 1.707, n.s.) among the three groups.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other dorsal raphe nucleus serotonergic neuron resting membrane potential (mV) -61.82 ± 1.67 (43) -61.82 (mV) Data Table
Other dorsal raphe nucleus serotonergic GABAergic neuron resting membrane potential (mV) -64.91 ± 4.14 (10) -64.91 (mV) Data Table
Other dorsal raphe nucleus GABAergic neuron resting membrane potential (mV) -52.13 ± 17.17 (4) -52.13 (mV) Data Table
Other dorsal raphe nucleus serotonergic neuron spike threshold (mV) -27.36 ± 1.05 (43) -27.36 (mV) Data Table
Other dorsal raphe nucleus serotonergic GABAergic neuron spike threshold (mV) -31.06 ± 1.5 (10) -31.06 (mV) Data Table
Other dorsal raphe nucleus GABAergic neuron spike threshold (mV) -24.06 ± 7.04 (4) -24.06 (mV) Data Table
Other dorsal raphe nucleus serotonergic neuron spike amplitude (mV) 70.37 ± 2.65 (43) 70.37 (mV) Data Table
Other dorsal raphe nucleus serotonergic GABAergic neuron spike amplitude (mV) 68.94 ± 3.94 (10) 68.94 (mV) Data Table
Other dorsal raphe nucleus GABAergic neuron spike amplitude (mV) 45.3 ± 5.59 (4) 45.3 (mV) Data Table
Other dorsal raphe nucleus serotonergic neuron spike half-width (ms) 2.22 ± 0.12 (43) 2.22 (ms) Data Table
Other dorsal raphe nucleus serotonergic GABAergic neuron spike half-width (ms) 1.98 ± 0.24 (10) 1.98 (ms) Data Table
Other dorsal raphe nucleus GABAergic neuron spike half-width (ms) 1.78 ± 0.22 (4) 1.78 (ms) Data Table
Other dorsal raphe nucleus serotonergic neuron AHP amplitude (mV) -25.66 ± 1.22 (43) 25.66 (mV) Data Table
Other dorsal raphe nucleus serotonergic GABAergic neuron AHP amplitude (mV) -24.14 ± 1.31 (10) 24.14 (mV) Data Table
Other dorsal raphe nucleus GABAergic neuron AHP amplitude (mV) -29.0 ± 7.91 (4) 29.0 (mV) Data Table