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Article: Ventral tegmental area glutamate neurons: electrophysiological properties and projections.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hnasko TS; Hjelmstad GO; Fields HL; Edwards RH
J. Neurosci., 2012


Table 1.

Basic membrane properties and action potential characteristics of neurons in the VTA

Vm (mv) Firing rate (Hz) AP threshold (mV) AP duration (ms) AHP peak (mV) AHP time to peak (ms) AHP at 50 ms (mV)
Medial glut -59.6 ± 1.6* 3.7 ± 0.8 -41.3 ± 0.9* 2.6 ± 0.2* -68.6 ± 2.0* 15.4 ± 3.2 -62.2 ± 1.2
Medial DA -54.7 ± 1.3 2.9 ± 0.4 -38.1 ± 0.9 3.3 ± 0.2 -62.5 ± 1.7 19.0 ± 2.2 -58.6 ± 1.6
Lateral DA -56.8 ± 0.9 1.1 ± 0.3** -41.7 ± 1.0* 2.8 ± 0.1 -73.1 ± 1.8*** 28.2 ± 5.2 -71.7 ± 1.9***

  • ↵Statistically significant difference relative to medial dopamine neurons, two-tailed t test, *p < 0.05,

  • ↵**p < 0.01,

  • ↵***p < 0.001. Vm, initial membrane potential; AP, action potential; AHP, afterhyperpolarization.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron resting membrane potential -54.7 ± 1.3 (20) -54.7 (mV) Data Table
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron firing frequency (Hz) 2.9 ± 0.4 (20) 2.9 (Hz) Data Table
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron spike threshold (mV) -38.1 ± 0.9 (20) -38.1 (mV) Data Table
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron spike width (ms) 3.3 ± 0.2 (20) 3.3 (ms) Data Table
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron AHP voltage (mV) -62.5 ± 1.7 (20) -62.5 (mV) Data Table
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron fast AHP duration (ms) 19.0 ± 2.2 (20) 19.0 (ms) Data Table
Ventral tegmental area dopamine neuron Medial ventral tegmental area dopamine Slc6a3-expressing neuron fast AHP voltage (mV) -58.6 ± 1.6 (20) -58.6 (mV) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron resting membrane potential -56.8 ± 0.9 (20) -56.8 (mV) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron firing frequency (Hz) 1.1 ± 0.3 (20) 1.1 (Hz) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron resting membrane potential -59.6 ± 1.6 (14) -59.6 (mV) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron spike threshold (mV) -41.7 ± 1.0 (20) -41.7 (mV) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron spike width (ms) 2.8 ± 0.1 (20) 2.8 (ms) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron AHP voltage (mV) -73.1 ± 1.8 (20) -73.1 (mV) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron fast AHP duration (ms) 28.2 ± 5.2 (20) 28.2 (ms) Data Table
Ventral tegmental area dopamine neuron Lateral ventral tegmental area dopamine Slc6a3-expressing neuron fast AHP voltage (mV) -71.7 ± 1.9 (20) -71.7 (mV) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron firing frequency (Hz) 3.7 ± 0.8 (14) 3.7 (Hz) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron spike threshold (mV) -41.3 ± 0.9 (14) -41.3 (mV) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron spike width (ms) 2.6 ± 0.2 (14) 2.6 (ms) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron AHP voltage (mV) -68.6 ± 2.0 (14) -68.6 (mV) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron fast AHP duration (ms) 15.4 ± 3.2 (14) 15.4 (ms) Data Table
Other Medial ventral tegmental area glutamate Slc17a6-expressing neuron fast AHP voltage (mV) -62.2 ± 1.2 (14) -62.2 (mV) Data Table