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Article: Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.

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Péterfi Z; Urbán GM; Papp OI; Németh B; Monyer H; Szabó G; Erdélyi F; Mackie K; Freund TF; Hájos N; Katona I
J. Neurosci., 2012


Table 1.

Physiological properties of the recorded interneurons

Fast-spiking basket cells (n = 10) Axo-axonic cells (n = 10) Bistratified cells (n = 10) O-LM cells (n = 10)
Input resistance (MΩ) 70.82 (60.94-88.64)a 111.41 (70.96-137.1) 117.26 (91.01-146.6) 136.8 (86.59-199)
Membrane time constant (ms) 9.17 (7.06-11.83) 10.58 (9.39-11.41) 9.68 (8.71-14.32) 18.14 (12.58-25.58)
Membrane capacitance (pF) 119 (84-141) 89 (81-125) 97 (79-103) 144 (124-159)
Relative sag amplitude 0.191 (0.139-0.217) 0.168 (0.133-0.176) 0.092 (0.078-0.167)b 0.500 (0.396-0.761)
AP amplitude (mV) 61.3 (53.9-63.3) 65.3 (60.6-70.5) 64.4 (59.8-77) 72.8 (57.8-78)
AP width at half-maximum (ms) 0.4 (0.4-0.5) 0.5 (0.4-0.5) 0.4 (0.3-0.5) 0.6 (0.5-0.8)
AHP amplitude (mV) 15.5 (12.8-18) 14.8 (8.6-16.7)c 17.9 (16-20.5) 18.9 (16.6-22)
Spike frequency (Hz) at small current stepsd 51 (50-64) 43 (41-83) 65 (58-101) 29 (18-49)
Accommodation index at small current stepsd 1.67 (1.33-1.93) 2.02 (1.49-3) 1.61 (1.5-1.9) 1.66 (1.52-2.28)
Spike frequency (Hz) at large current stepse 61 (50-84) 77 (56-114) 66 (41-101) 65 (51-78)
Accommodation index at large current stepse 1.76 (1.54-1.93) 1.8 (1.16-3.28) 1.94 (1.5-2.41) 1.9 (1.55-2.82)

  • Data are presented as the median and the interquartile range in parentheses. Values indicated with bold differ significantly (p < 0.05) from all other cell types, while values in italics indicate significant differences from two other cell types. AP, Action potential; AHP, afterhyperpolarization.

  • ↵aFS BC versus AAC, p = 0.143; FS BC versus BIST, p = 0.015; FS BC versus O-LM, p = 0.002.

  • ↵bBIST versus AAC, p = 0.222; BIST versus BC, p = 0.022; BIST versus O-LM, p < 0.001.

  • ↵cAAC versus FS BC, p = 0.356; AAC versus BIST, p = 0.043; AAC versus O-LM, p = 0.015.

  • ↵dVoltage responses at which interneurons were capable to discharge continuously during the entire trace upon the smallest current injection (150-400 pA range for FS IN and 50-250 pA for O-LM cells) were compared.

  • ↵eVoltage responses at which interneurons fired with the highest frequency were compared.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 oriens lacunosum moleculare neuron membrane time constant (ms) 18.14 18.14 (ms) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons cell capacitance (pF) 119.0 119.0 (pF) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons cell capacitance (pF) 89.0 89.0 (pF) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons cell capacitance (pF) 97.0 97.0 (pF) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron cell capacitance (pF) 144.0 144.0 (pF) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons sag ratio 0.191 0.191 (ratio) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons sag ratio 0.168 0.168 (ratio) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons sag ratio 0.092 0.092 (ratio) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons input resistance (MΩ) 70.82 70.82 (MΩ) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron sag ratio 0.5 0.5 (ratio) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons spike amplitude (mV) 61.3 61.3 (mV) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons spike amplitude (mV) 65.3 65.3 (mV) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons spike amplitude (mV) 64.4 64.4 (mV) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron spike amplitude (mV) 72.8 72.8 (mV) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons spike half-width (ms) 0.4 0.4 (ms) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons spike half-width (ms) 0.5 0.5 (ms) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons spike half-width (ms) 0.4 0.4 (ms) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons input resistance (MΩ) 111.41 111.41 (MΩ) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron spike half-width (ms) 0.6 0.6 (ms) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons AHP amplitude (mV) 15.5 15.5 (mV) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons AHP amplitude (mV) 14.8 14.8 (mV) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons AHP amplitude (mV) 17.9 17.9 (mV) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron AHP amplitude (mV) 18.9 18.9 (mV) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons input resistance (MΩ) 117.26 117.26 (MΩ) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons maximum firing rate (Hz) 61.0 61.0 (Hz) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons maximum firing rate (Hz) 77.0 77.0 (Hz) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons maximum firing rate (Hz) 66.0 66.0 (Hz) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron input resistance (MΩ) 136.8 136.8 (MΩ) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron maximum firing rate (Hz) 65.0 65.0 (Hz) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons adaptation ratio (last/first ISI) (at) 1.76 1.76 (ratio) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons adaptation ratio (last/first ISI) (at) 1.8 1.8 (ratio) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons adaptation ratio (last/first ISI) (at) 1.94 1.94 (ratio) Data Table
Hippocampus CA1 oriens lacunosum moleculare neuron adaptation ratio (last/first ISI) (at) 1.9 1.9 (ratio) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 fast-spiking basket interneurons membrane time constant (ms) 9.17 9.17 (ms) Data Table
Dentate gyrus axo-axonic cell Dentate gyrus fast-spiking axo-axnonic interneurons membrane time constant (ms) 10.58 10.58 (ms) Data Table
Other Hippocampal CA1 fast-spiking bistratified interneurons membrane time constant (ms) 9.68 9.68 (ms) Data Table