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Article: Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.

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Péterfi Z; Urbán GM; Papp OI; Németh B; Monyer H; Szabó G; Erdélyi F; Mackie K; Freund TF; Hájos N; Katona I
J. Neurosci., 2012


Table 3.

Effects of DHPG on EPSC amplitudes in distinct cell types and the outcome of different drug treatments or genetic inactivation of CB1 receptors on the magnitude of chemical LTD

Pyramidal cell FS IN O-LM cell
n p n p n p
10 μm DHPG 0.346 ± 0.071 5 <0.001 1.019 ± 0.049 9 0.165 0.891 ± 0.026 5 0.315
50 μm DHPG 0.483 ± 0.049 11 <0.001 0.258 ± 0.064 11 <0.001 0.333 ± 0.029 5 0.002
+MPEP 1.006 ± 0.177 7 0.011 1.064 ± 0.075 7 <0.001 0.989 ± 0.038 8 <0.001
+LY 367385 0.738 ± 0.070 3 0.007 0.676 ± 0.069 3 0.013 1.281 ± 0.265 6 0.021
+BAPTA, 0 mm Ca2+ 0.870 ± 0.026 5 <0.001 1.027 ± 0.066 3 0.001 0.937 ± 0.039 3 0.001
+BAPTA, 2 mm Ca2+ 1.021 ± 0.028 7 <0.001 1.022 ± 0.073 5 <0.001 0.99 ± 0.036 4 <0.001
+THL 1.079 ± 0.105 5 0.003 0.962 ± 0.073 7 0.002 1.011 ± 0.044 6 <0.001
+AM 251 0.519 ± 0.051 4 0.143 0.930 ± 0.073 5 <0.001 1.309 ± 0.380 6 0.072
CB1 KO 1.038 ± 0.043 8 <0.001 0.985 ± 0.035 8 <0.001 1.099 ± 0.144 3 <0.001
  • Data are expressed as mean ± SEM. Student's paired t test was used to evaluate the significant changes upon 10 or 50 μm DHPG treatments (first two rows). In all other cases, independent-samples t test was used for statistical comparison. The p values are the results of the comparisons between the data obtained upon 50 μm DHPG application in the absence and the presence of different drugs, or in the measurements conducted in slices prepared from wild-type or CB1 knock-out mice.


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