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Article: Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.

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Kron M; Howell CJ; Adams IT; Ransbottom M; Christian D; Ogier M; Katz DM
J. Neurosci., 2012


Table 1.

Quantification of Fos expression in selected brain regions in Null vs Wt mice

Male Wt Male Null
Medulla n = 7 n = 7
    Medial nTS 106.5 ± 0.5 326.4 ± 0.9***
    Lateral nTS 137.9 ± 0.7 447.9 ± 2.0***
    Commissural nTS 21.8 ± 0.2 53.4 ± 0.5*
    Nucleus retroambiguus 7.9 ± 1.2 11.9 ± 2.2#
    preBotzinger Complex 23.6 ± 7.4 29.1 ± 4.7
Pons n = 5 n = 5
    Pontine nucleus 322.7 ± 63.7 199.4 ± 51.5
Midbrain n = 5 n = 5
    Dorsal PAG 21.6 ± 32.8 13.9 ± 4.7
    Lateral PAG 53.0 ± 25.2 35.9 ± 10.7#
    Ventral PAG 39.7 ± 12.3 25.6 ± 7.5*
Forebrain n = 5 n = 5
    Piriform cortex 266.3 ± 35.0 124.2 ± 19.7*
    Nucleus accumbens 114.4 ± 22.8 26.8 ± 7.9**
    Cingulate cortex 50.4 ± 13.08 14.8 ± 4.8*
    Retrosplenial cortex 39.7 ± 10.86 7.4 ± 1.6*
    Prelimbic cortex 34.6 ± 6.81 8.4 ± 3.6**
    Infralimbic cortex 26.6 ± 3.8 7.0 ± 2.2**
    Motor cortex 19.9 ± 3.8 3.1 ± 1.6**
    Lateral septal nucleus 48.6 ± 14.9 11.6 ± 4.9*
    Hippocampus (CA1 + CA3) 22.5 ± 8.3 14.0 ± 4.6
    Hippocampus (DG) 14.3 ± 4.7 9.5 ± 2.6
  • Data are displayed as mean ± SEM (*p < 0.05; **p < 0.01; ***p < 0.001;

  • #p < 0.15).


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Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source