Table 1.
Experimental cohort used to narrow down the 5-HT-sensitive developmental time window
| Experimental cohort | Treatment | Time | Animals | Males | Females | Litter | Mice per litter | Male mice per litter | Female mice per litter | Females/total |
|---|---|---|---|---|---|---|---|---|---|---|
| Sensitive period, OF, NSF, SESC (Fig. 1) | VEH | P2-P21 | 20 | 10 | 10 | A | 6 | 3 | 3 | 0.50 |
| VEH | P2-P21 | B | 5 | 2 | 3 | 0.60 | ||||
| VEH | P2-P21 | C | 5 | 2 | 3 | 0.60 | ||||
| VEH | P2-P21 | D | 4 | 1 | 3 | 0.75 | ||||
| FLX | P2-P21 | 20 | 11 | 9 | A | 6 | 4 | 2 | 0.33 | |
| FLX | P2-P21 | B | 5 | 5 | 0 | 0.00 | ||||
| FLX | P2-P21 | C | 4 | 1 | 3 | 0.75 | ||||
| FLX | P2-P21 | D | 5 | 1 | 4 | 0.80 | ||||
| VEH | P2-P11 | 24 | 12 | 12 | A | 6 | 2 | 4 | 0.67 | |
| VEH | P2-P11 | B | 6 | 3 | 3 | 0.50 | ||||
| VEH | P2-P11 | C | 6 | 3 | 3 | 0.50 | ||||
| VEH | P2-P11 | D | 6 | 4 | 2 | 0.33 | ||||
| FLX | P2-P11 | 23 | 11 | 12 | A | 5 | 2 | 3 | 0.60 | |
| FLX | P2-P11 | B | 5 | 2 | 3 | 0.60 | ||||
| FLX | P2-P11 | C | 4 | 3 | 1 | 0.25 | ||||
| FLX | P2-P11 | D | 5 | 3 | 2 | 0.40 | ||||
| FLX | P2-P11 | E | 4 | 1 | 3 | 0.75 | ||||
| VEH | P12-P21 | 19 | 11 | 8 | A | 5 | 1 | 4 | 0.80 | |
| VEH | P12-P21 | B | 6 | 4 | 2 | 0.33 | ||||
| VEH | P12-P21 | C | 5 | 4 | 1 | 0.20 | ||||
| VEH | P12-P21 | D | 4 | 3 | 1 | 0.25 | ||||
| FLX | P12-P21 | 23 | 11 | 12 | A | 8 | 3 | 5 | 0.63 | |
| FLX | P12-P21 | B | 5 | 2 | 3 | 0.60 | ||||
| FLX | P12-P21 | C | 6 | 3 | 3 | 0.50 | ||||
| FLX | P12-P21 | D | 3 | 2 | 1 | 0.33 | ||||
| VEH | P22-P41 | 19 | 12 | 7 | A | 7 | 3 | 4 | 0.57 | |
| VEH | P22-P41 | B | 6 | 5 | 1 | 0.17 | ||||
| VEH | P22-P41 | C | 6 | 4 | 2 | 0.33 | ||||
| FLX | P22-P41 | 24 | 13 | 11 | A | 7 | 4 | 3 | 0.43 | |
| FLX | P22-P41 | B | 7 | 3 | 4 | 0.57 | ||||
| FLX | P22-P41 | C | 5 | 3 | 2 | 0.40 | ||||
| FLX | P22-P41 | D | 5 | 3 | 2 | 0.40 | ||||
| Total | 172 | 91 | 81 | 32 | 172 | 89 | 83 | |||
| Average litter size: | 5.4 | Average sex composition: | 0.48 |