AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Lacroix A; Toussay X; Anenberg E; Lecrux C; Ferreirós N; Karagiannis A; Plaisier F; Chausson P; Jarlier F; Burgess SA; Hillman EM; Tegeder I; Murphy TH; Hamel E; Cauli B
J. Neurosci., 2015


Table 5.

Physiological parameters in rats during whisker stimulation

Compound Condition MAP, mmHg HR, beats/min pH pCO2, mmHg pO2, mmHg
AH 6809 Control 79.1 ± 5.6 382.7 ± 14.4 7.44 ± 0.02 41.7 ± 0.6 90.7 ± 3.2
Vehicle 78.9 ± 5.8 374.6 ± 17.5 7.43 ± 0.01 42.7 ± 1.6 91.3 ± 3.0
MAP, HR Drug 79.2 ± 5.3 376.7 ± 20.3 7.44 ± 0.01 41.3 ± 0.9 90.0 ± 3.0
(n = 6 rats) Q(2,6) = 1.00000 Q(2,6) = 0.3333333 Q(2,4) = 1.50000 F(2,8) = 0.04450 F(2,8) = 1.027
pH (n = 4 rats) p = 0.60653 p = 0.84648 p = 0.47237 p = 0.9074 p = 0.3974
pCO2, pO2 n.s. n.s. n.s. n.s. n.s.
(n = 5 rats)
L 161-982 Control 74.7 ± 4.9 398.2 ± 37.3 7.42 ± 0.01 36.0 ± 4.8 101.1 ± 9.7
Vehicle 74.3 ± 6.5 401.9 ± 43.8 7.43 ± 0.01 38.5 ± 1.6 91.4 ± 1.5
MAP, HR, pH, pO2 Drug 73.5 ± 6.8 377.5 ± 30.0 7.42 ± 0.02 36.3 ± 3.8 105.6 ± 7.7
(n = 4 rats) F(2,6) = 0.1294 F(2,6) = 2.689 F(2,6) = 0.2572 F(2,4) = 0.7467 F(2,6) = 1.621
pCO2 p = 0.8037 p = 0.1930 p = 0.7263 p = 0.4786 p = 0.2923
(n = 3 rats) n.s. n.s. n.s. n.s. n.s.
CAY 10441 Control 76.1 ± 5.2 384.3 ± 13.0 7.42 ± 0.01 38.4 ± 2.8 96.6 ± 1.7
Vehicle 78.3 ± 6.6 394.3 ± 16.8 7.42 ± 0.01 40.9 ± 2.0 93.4 ± 3.4
(n = 5 rats) Drug 77.5 ± 6.1 371.2 ± 14.8 7.42 ± 0.02 38.8 ± 1.9 89.9 ± 3.6
F(2,8) = 1.046 F(2,8) = 2.112 Q(2,5) = 1.20000 Q(2,5) = 2.80000 F(2,8) = 4.616
p = 0.3676 p = 0.2090 p = 0.54881 p = 0.2466 p = 0.0970
n.s. n.s. n.s. n.s. n.s.

  • Mean arterial blood pressure (MAP), heart rate (HR), pH, and blood gases (pCO2 and pO2) were measured during whisker-induced CBF responses under control conditions, as well as after vehicle and drug infusion. None of the compounds used affected physiological parameters. The number of rats is indicated within parentheses. Repeated-measures ANOVA (F) or Friedman test (Q) and corresponding exact p values. n.s.; not statistically significant.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source