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Article: Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.

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Proulx É; Fraser P; McLaurin J; Lambe EK
J. Neurosci., 2015


Table 1.

Electrophysiological properties of PFC layer 6 pyramidal neurons of TgCRND8 mice and littermate WT controls

WT TgCRND8 P
Capacitance (pF) 72 ± 2 71 ± 2 0.5
Input resistance (MΩ) 313 ± 18 285 ± 16 0.2
Membrane potential (mV) -83 ± 1 -85 ± 1 0.3
Spike threshold (mV) -52 ± 0.4 -51 ± 0.5 0.4
Spike amplitude (mV) 79 ± 1 80 ± 1 0.5

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 prefrontal cortex layer 6 pyramidal neuron resting membrane potential (mV) -83.0 ± 1.0 -83.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 prefrontal cortex layer 6 pyramidal neuron spike threshold (mV) -52.0 ± 0.4 -52.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 prefrontal cortex layer 6 pyramidal neuron spike amplitude (mV) 79.0 ± 1.0 79.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 prefrontal cortex layer 6 pyramidal neuron cell capacitance (pF) 72.0 ± 2.0 72.0 (pF) Data Table
Neocortex pyramidal cell layer 5-6 prefrontal cortex layer 6 pyramidal neuron input resistance (MΩ) 313.0 ± 18.0 313.0 (MΩ) Data Table