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Article: Trace Fear Conditioning Differentially Modulates Intrinsic Excitability of Medial Prefrontal Cortex-Basolateral Complex of Amygdala Projection Neurons in Infralimbic and Prelimbic Cortices.

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Song C; Ehlers VL; Moyer JR
J. Neurosci., 2015


Table 1.

Effect of trace fear conditioning and extinction on membrane properties of regular spiking mPFC-BLA projection neurons

Group RMP (mV) RN (MΩ) Ithreshold (pA) APthresh (mV) APamp (mV) APwidth (μs) mAHP (mV) sAHP (mV) Sag (%)
Infralimbic cortex
    NAIVE -60.7 ± 1.2 (21) 123 ± 9 (21) 147 ± 12 (20) -29.5 ± 1.2 (20)* 77 ± 2 (20) 971 ± 49 (20) -4.2 ± 0.3 (20)* -0.9 ± 0.1 (20) 9.2 ± 1.0 (18)*
    PSEUDO -64.1 ± 1.3 (18) 104 ± 8 (18) 154 ± 14 (18) -31.2 ± 0.9 (18) 78 ± 2 (18) 950 ± 36 (18) -4.9 ± 0.4 (18) -0.8 ± 0.1 (18) 10.8 ± 0.9 (18)
    TRACE -62.5 ± 1.2 (22) 118 ± 9 (22) 137 ± 8 (22) -32.8 ± 0.8 (22) 78 ± 1 (22) 968 ± 42 (22) -5.1 ± 0.3 (22) -0.7 ± 0.1 (22) 13.2 ± 1.0 (22)
    TRACE-RET -61.8 ± 1.2 (13) 99 ± 8 (13) 150 ± 15 (12) -29.8 ± 1.1 (12)* 75 ± 2 (12) 912 ± 26 (12) -4.7 ± 0.4 (13) -0.7 ± 0.2 (13) 9.7 ± 1.1 (13)
    EXT -61.3 ± 1.1 (23) 107 ± 6 (23) 147 ± 10 (23) -31.5 ± 0.7 (23) 78 ± 1 (23) 912 ± 34 (23) -4.8 ± 0.2 (22) 1.0 ± 0.1 (22) 11.7 ± 1.1 (22)
    EXT-RET -62.1 ± 1.0 (24) 108 ± 6 (24) 144 ± 12 (24) -31.8 ± 0.8 (24) 81 ± 2 (24) 840 ± 29 (24) -4.8 ± 0.3 (22) 0.9 ± 0.1 (22) 12.2 ± 1.1 (21)
Prelimbic cortex
    NAIVE -61.7 ± 0.4 (12) 105 ± 6 (12)* 135 ± 14 (12)* -30.6 ± 1.6 (12) 80 ± 2 (12) 818 ± 37 (12) -4.8 ± 0.3 (12) -0.9 ± 0.1 (12) 11.7 ± 2.1 (9)
    PSEUDO -62.0 ± 1.3 (9) 86 ± 10 (9) 154 ± 14 (9) -30.9 ± 1.9 (9) 82 ± 1 (9) 780 ± 23 (9) -6.0 ± 0.4 (9) -1.0 ± 0.1 (9) 13.2 ± 2.3 (9)
    TRACE -63.4 ± 0.9 (14) 80 ± 11 (14) 188 ± 15 (14) -32.2 ± 0.6 (14) 85 ± 2 (14) 846 ± 35 (14) -4.8 ± 0.3 (14) -0.9 ± 0.1 (14) 12.4 ± 1.1 (14)
    TRACE-RET -63.0 ± 1.5 (15) 101 ± 9 (15) 140 ± 13 (14)* -31.5 ± 0.9 (14) 80 ± 2 (14) 750 ± 26 (14) -4.9 ± 0.3 (15) -1.0 ± 0.1 (13) 9.4 ± 1.0 (13)
    EXT -61.3 ± 1.2 (22) 93 ± 5 (22) 165 ± 12 (22)* -31.3 ± 0.8 (22) 82 ± 2 (22) 829 ± 26 (22) -4.6 ± 0.3 (22) -0.6 ± 0.1 (22) 11.8 ± 1.0 (22)
    EXT-RET -62.8 ± 1.5 (15) 94 ± 9 (15) 144 ± 15 (15) -33.5 ± 0.9 (15) 85 ± 2 (15) 798 ± 31 (15) -4.7 ± 0.4 (13) -0.8 ± 0.1 (13) 11.4 ± 1.4 (13)
  • Data are mean ± SE for the number of cells in parentheses. Rat groups are as follows: NAIVE, rats that did not receive any behavioral training; PSEUDO, rats that received pseudoconditioning on day 1 and tested on day 4; TRACE, rats that received trace fear conditioning on day 1 and tested on day 4; TRACE-RET, rats that received trace fear conditioning on day 1 and tested on day 11; EXT, rats that received trace fear conditioning on day 1, extinction on days 2-3, and tested on day 4; EXT-RET, rats that received conditioning on day 1, extinction on days 2-3, and tested on day 11. APamp was relative to threshold. The mAHP was measured at the peak of the AHP within 150 ms after a burst of 10 APs. The sAHP was measured at 1 s after the burst of 10 APs.

  • *p < 0.05, statistically different from TRACE.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala resting membrane potential (mV) -60.7 ± 1.2 (21) -60.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala input resistance (MΩ) 123.0 ± 9.0 (21) 123.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala rheobase (pA) 147.0 ± 12.0 (20) 147.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala spike threshold (mV) -29.5 ± 1.2 (20) -29.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala spike amplitude (mV) 77.0 ± 2.0 (20) 77.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala spike width (μs) 971.0 ± 49.0 (20) 0.971 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala medium AHP amplitude (mV) -4.2 ± 0.3 (20) 4.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala slow AHP amplitude (mV) -0.9 ± 0.1 (20) 0.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Infralimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala sag ratio 9.2 ± 1.0 (18) 0.092 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala resting membrane potential (mV) -61.7 ± 0.4 (12) -61.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala input resistance (MΩ) 105.0 ± 6.0 (12) 105.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala rheobase (pA) 135.0 ± 14.0 (12) 135.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala spike threshold (mV) -30.6 ± 1.6 (12) -30.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala spike amplitude (mV) 80.0 ± 2.0 (12) 80.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala spike width (μs) 818.0 ± 37.0 (12) 0.818 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala medium AHP amplitude (mV) -4.8 ± 0.3 (12) 4.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala slow AHP amplitude (mV) -0.9 ± 0.1 (12) 0.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prelimbic Medial Prefrontal Cortex Layer V Regular Spiking Pyramidal Neuron Projecting to the Basolateral Complex of Amygdala sag ratio 11.7 ± 2.1 (9) 0.117 (ratio) Data Table