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Article: Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Lavin A; Grace AA
Neuroscience, 2001


Control (n=10)Dopamine
Membrane potential (mV)74.2±8.366.4±9.7*
Spike threshold (mV)48.6±7.049.5±7.1
Current threshold (pA)50±3871±46
Spike amplitude (mV)56.4±5.663.4±8.7
Amplitude AHP (mV)12.0±8.43.6±1.9
Input resistance (MΩ)47.1±16.936.5±26.4
Excitability (slope #spikes/I)0.37±0.220.49±0.41

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5-6 pyramidal neuron spike amplitude (mV) 56.4 ± 5.6 56.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5-6 pyramidal neuron AHP amplitude (mV) 12.0 ± 8.4 12.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5-6 pyramidal neuron input resistance (MΩ) 47.1 ± 16.9 47.1 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5-6 pyramidal neuron resting membrane potential (mV) 74.2 ± 8.3 -74.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5-6 pyramidal neuron spike threshold (mV) 48.6 ± 7.0 -48.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5-6 pyramidal neuron rheobase (pA) 50.0 ± 38.0 50.0 (pA) Data Table