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Article: Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function.

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Kim EJ; Juavinett AL; Kyubwa EM; Jacobs MW; Callaway EM
Neuron, 2015


Table S1: Electrophysiological Properties of Three Classes of Layer 5 Neurons, related to Figure 2.
Tlx3-Cre Glt25d2-Cre L5 Efr3a-Cre Statistical Comparisons
Input resistance (MΩ) 120.908 ± 6.678 (17) 146.365 ± 14.527 (11) 263.372 ± 52.722 (9) Efr3a>Glt25d2*, Efr3a>Tlx3*
Percent sag (%) 6.57 ± 0.88 (16) 22.19 ± 1.34 (9) 20.93 ± 2.05 (9) Efr3a>Tlx3****, Glt25d2>Tlx3****
Sag amplitude (mV) 2.46 ± 0.37 (16) 10.99 ± 1.57 (9) 11.60 ± 1.07 (9) Efr3a>Tlx3****, Glt25d2>Tlx3****
ISI_1/ISI_mean 0.568 ± 0.024 (17) 0.197 ± 0.024 (11) 0.443 ± 0.086 (9) Efr3a>Glt25d2**, Tlx3>Glt25d2****
Adaptation index 0.026 ± 0.003 (17) 0.036 ± 0.007 (11) 0.030 ± 0.009 (9)
Capacitance (pF) 26.30 ± 1.907 (6) 159.4 ± 18.49 (5) 19.77 ± 3.348 (7) Glt25d2>Tlx3****, Glt25d2>Efr3a****
AP amplitude (mV) 74.52 ± 2.96 (17) 73.22 ± 2.32 (11) 68.32 ± 3.89 (9)
AP half-width (ms) 2.80 ± 0.47 (17) 2.48 ± 0.22 (11) 2.35 ± 0.25 (9)
AP rise rate (mV/s) 162.40 ± 14.35 (17) 123.54 ± 8.46 (11) 119.50 ± 19.24 (9)
AP decay rate (mV/s) -35.25 ± 3.11 (17) -29.92 ± 2.28 (11) -32.14 ± 6.57 (9)
RMP (mV) -65.67 ± 2.02 (16) -60.68 ± 1.55 (9) -57.29 ± 1.38 (9)
Shown are mean +\- SEM. For multiple comparisons, one-way ANOVA with Tukey post-hoc test was used. *p

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron sag amplitude (mV) 2.46 ± 0.37 (16) 2.46 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron sag amplitude (mV) 10.99 ± 1.57 (9) 10.99 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron sag amplitude (mV) 11.6 ± 1.07 (9) 11.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron adaptation ratio 0.568 ± 0.024 (17) 0.568 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron adaptation ratio 0.197 ± 0.024 (11) 0.197 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron adaptation ratio 0.443 ± 0.086 (9) 0.443 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron input resistance (MΩ) 120.908 ± 6.678 (17) 120.908 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron adaptation ratio (other) 0.026 ± 0.003 (17) 0.026 (None) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron adaptation ratio (other) 0.036 ± 0.007 (11) 0.036 (None) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron adaptation ratio (other) 0.03 ± 0.009 (9) 0.03 (None) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron cell capacitance (pF) 26.3 ± 1.907 (6) 26.3 (pF) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron cell capacitance (pF) 159.4 ± 18.49 (5) 159.4 (pF) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron cell capacitance (pF) 19.77 ± 3.348 (7) 19.77 (pF) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron input resistance (MΩ) 146.365 ± 14.527 (11) 146.365 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike amplitude (mV) 74.52 ± 2.96 (17) 74.52 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike amplitude (mV) 73.22 ± 2.32 (11) 73.22 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike amplitude (mV) 68.32 ± 3.89 (9) 68.32 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike half-width (ms) 2.8 ± 0.47 (17) 2.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike half-width (ms) 2.48 ± 0.22 (11) 2.48 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike half-width (ms) 2.35 ± 0.25 (9) 2.35 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron input resistance (MΩ) 263.372 ± 52.722 (9) 263.372 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike rise time (mV/s) 162.4 ± 14.35 (17) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike rise time (mV/s) 123.54 ± 8.46 (11) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike rise time (mV/s) 119.5 ± 19.24 (9) -- Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron spike decay time (mV/s) -35.25 ± 3.11 (17) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron spike decay time (mV/s) -29.92 ± 2.28 (11) -- Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron spike decay time (mV/s) -32.14 ± 6.57 (9) -- Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron resting membrane potential (mV) -65.67 ± 2.02 (16) -65.67 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron resting membrane potential (mV) -60.68 ± 1.55 (9) -60.68 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron resting membrane potential (mV) -57.29 ± 1.38 (9) -57.29 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual cortex layer 5 Tlx3-expressing corticocortical regular spiking slender-tufted pyramidal neuron sag ratio 6.57 ± 0.88 (16) 0.0657 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Glt25d2-expressing corticopontine intrinsically bursting thick-tufted pyramidal neuron sag ratio 22.19 ± 1.34 (9) 0.2219 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 Efr3a-expressing corticocortical cortico-nonstriatal projecting regular spiking slender-tufted pyramidal neuron sag ratio 20.93 ± 2.05 (9) 0.2093 (ratio) Data Table