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Article: Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.

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Tamagnini F; Novelia J; Kerrigan TL; Brown JT; Tsaneva-Atanasova K; Randall AD
Front Cell Neurosci, 2015


Resonance properties of CA1-PCs in hippocampal slices from 20 to 23 month old PDAPP mice and age-matched WT littermate controls.

WT n = 26 PDAPP n = 30
Property Average SEM Average SEM p
Peak frequency (Hz) 3.73 0.37 3.77 0.28 0.93
Q 1.11 0.02 1.11 0.01 0.86
Peak Z (MΩ) 90.34 9.45 100.99 7.90 0.39

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