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Article: Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.

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Ghosh A; Purchase NC; Chen X; Yuan Q
Front Cell Neurosci, 2015


The effects of 10 μM NE on pyramidal cell intrinsic properties.

P8-11 (n = 8) P14+ (n = 9)


Control NE 10μM NE Wash F(2,21) P Control NE 10μM NE Wash F(2,24) P
AP threshold (mV) -36.1±1.5 -35.4±1.9 -36.3±2.1 0.07 0.93 -38.2±2.4 -38.4±2.4 -40.8±2.1 0.37 0.69
AP amplitude (mV) 68.1±2.9 66.8±2.3 62.9±2.5 1.11 0.35 75.7±2.8 72.9±3.3 70.5±3.7 0.63 0.54
AP half width (ms) 1.40±0.09 1.35±0.06 1.37±0.05 0.12 0.89 1.02±0.04 1.00±0.03 0.94±0.04 1.25 0.3
AP rising time (ms) 0.37±0.03 0.36±0.02 0.40±0.02 0.73 0.49 0.30±0.02 0.30±0.01 0.31±0.01 0 1
AP decay time (ms) 1.18±0.10 1.13±0.09 1.05±0.05 0.66 0.53 0.76±0.03 0.70±0.02 0.63±0.04 4.69 0.02
RMP (mV) -63.4±3.1 -63.2±2.8 -65.2±3.7 0.12 0.89 -64.7±3.8 -63.9±4.0 -65.1±4.2 0.02 0.98
Rm (MΩ) 305.3±23.4 338.1±26.7 299.6±27.4 0.64 0.54 243.7±28.4 245.1±32.7 241.2±29.8 0 1
p < 0.05.

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