Article: Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices.
Basal electrophysiological parameters of neurons in ACSF or sucrose prepared slices, and after dopamine or isoproterenol treatment of sucrose prepared slices.
ACSF (n = 51)
SUCROSE (n = 43)
+DA (n = 17)
+ISO (n = 7)
RMP (mV)
-63.9 ± 1.4*
-58.7 ± 1.1
-70.4 ± 1.3
-59.7 ± 5.8
Rin (MΩ)
170.7 ± 17.3
171.7 ± 8.9
155.1 ± 13.8
159.4 ± 10.4
EPSPmean (mV)
6.4 ± 0.3
7.4 ± 0.6
6.9 ± 0.4
8.6 ± 0.7
EPSPrise time (ms)
6.9 ± 0.3
6.6 ± 0.4
5.1 ± 0.2
4.6 ± 0.2
EPSPhalf width (ms)
39.0 ± 1.7
38.3 ± 1.6
30.9 ± 0.9
32.6 ± 2.1
Age (days)
16.4 ± 0.3
17.1 ± 0.3
17.8 ± 0.3
16.1 ± 0.4
Data are given as mean ± SEM, p > 0.05 ANOVA. *Significantly different from sucrose (using two-tailed Student’s t-test), when only ACSF and sucrose group are compared. When data from all four groups are compared (using ANOVA), no significant differences exist.
