Article: Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices.
Comparison of action potential parameters (compare Figures 5 and 7) in ACSF and sucrose prepared hippocampal slices, and after dopamine or isoproterenol treatment of sucrose prepared slices.
ACSF (n = 9)
SUCROSE (n = 22)
+DA (n = 9)
+ISO (n = 10)
Threshold (mV)
-45.6 ± 0.9
-41.1 ± 1.3
-50.0 ± 1.9*
-46.5 ± 1.9
Amplitude (mV)
82.4 ± 1.7
73.8 ± 3.4
89.4 ± 3.1*
84.4 ± 3.6
Half width (ms)
1.3 ± 0.1
1.4 ± 0.2
1.0 ± 0.5*
1.0 ± 0.1
Area (mV*ms)
116.9 ± 4.1
124.8 ± 6.7
99.9 ± 3.0*
97.9 ± 3.7*
Decay time (ms)
1.2 ± 0.1
1.3 ± 0.1
0.9 ± 0.0*
1.0 ± 1.9*
All cells were held at -70 mV membrane potential prior to current injection (120 pA). Parameters were analyzed for the first action potential in a burst. Data are given as mean ± SEM, ANOVA with post hoc Tukey test: AP threshold: F(3,46) = 6.335; p < 0.01; AP amplitude: F(3,44) = 3.758; p < 0.05; AP half width: F(3,46) = 3.718; p < 0.05; AP area: F(3,46) = 4.554; p < 0.01, for DA vs. SUC and ISO vs. SUC; AP decay time: F(3,46) = 4.533; p < 0.01, for DA vs. SUC and ISO vs. SUC; *Indicates significance of differences from sucrose.