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Article: Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices.

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Edelmann E; Lessmann V
Front Synaptic Neurosci, 2011


Comparison of action potential parameters (compare Figures 5 and 7) in ACSF and sucrose prepared hippocampal slices, and after dopamine or isoproterenol treatment of sucrose prepared slices.

ACSF (n = 9) SUCROSE (n = 22) +DA (n = 9) +ISO (n = 10)
Threshold (mV) -45.6 ± 0.9 -41.1 ± 1.3 -50.0 ± 1.9* -46.5 ± 1.9
Amplitude (mV) 82.4 ± 1.7 73.8 ± 3.4 89.4 ± 3.1* 84.4 ± 3.6
Half width (ms) 1.3 ± 0.1 1.4 ± 0.2 1.0 ± 0.5* 1.0 ± 0.1
Area (mV*ms) 116.9 ± 4.1 124.8 ± 6.7 99.9 ± 3.0* 97.9 ± 3.7*
Decay time (ms) 1.2 ± 0.1 1.3 ± 0.1 0.9 ± 0.0* 1.0 ± 1.9*

All cells were held at -70 mV membrane potential prior to current injection (120 pA). Parameters were analyzed for the first action potential in a burst. Data are given as mean ± SEM, ANOVA with post hoc Tukey test: AP threshold: F(3,46) = 6.335; p < 0.01; AP amplitude: F(3,44) = 3.758; p < 0.05; AP half width: F(3,46) = 3.718; p < 0.05; AP area: F(3,46) = 4.554; p < 0.01, for DA vs. SUC and ISO vs. SUC; AP decay time: F(3,46) = 4.533; p < 0.01, for DA vs. SUC and ISO vs. SUC; *Indicates significance of differences from sucrose.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.3 ± 0.1 (9) 1.3 (ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -45.6 ± 0.9 (9) -45.6 (mV) Data Table
Hippocampus CA1 pyramidal cell spike decay time (ms) 1.2 ± 0.1 (9) 1.2 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 82.4 ± 1.7 (9) 82.4 (mV) Data Table