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Article: Reduced chemical and electrical connections of fast-spiking interneurons in experimental cortical dysplasia.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Zhou FW; Roper SN J. Neurophysiol., 2014
Kinetic parameters of EPSPs or IPSPs in different neuronal connections
| PV and Pyramid | PV and Stellate | PV and PV | |||
|---|---|---|---|---|---|
| PV→Pyramid | Pyramid→PV | PV→Stellate | Stellate→PV | PV→PV | |
| Connection rates | |||||
| Con | 27/81 (33.3%) | 20/81 (24.7%) | 25/72 (34.7%) | 21/72 (29.2%) | 29/41 (70.7%) |
| CD | 8/52 (15.4%)* | 14/52 (26.9%) | 7/45 (15.6%)* | 12/45 (26.7%) | 9/25 (36.0%)† |
| Amplitude, mV | |||||
| Con | 1.74 ± 0.19 | 2.34 ± 0.27 | 1.67 ± 0.21 | 2.27 ± 0.26 | 1.97 ± 0.18 |
| CD | 0.94 ± 0.13* | 2.53 ± 0.36 | 0.82 ± 0.12* | 2.41 ± 0.34 | 1.01 ± 0.13† |
| Failure rate, % | |||||
| Con | 1.23 ± 0.47 | 1.35 ± 0.56 | 1.27 ± 0.45 | 1.63 ± 0.71 | 1.12 ± 0.29 |
| CD | 5.42 ± 1.88* | 1.30 ± 0.92 | 5.64 ± 1.59† | 1.49 ± 0.94 | 5.86 ± 1.62† |
| CV of amplitude | |||||
| Con | 0.31 ± 0.03 | 0.29 ± 0.03 | 0.27 ± 0.02 | 0.32 ± 0.04 | 0.26 ± 0.02 |
| CD | 0.49 ± 0.05† | 0.25 ± 0.08 | 0.54 ± 0.07† | 0.30 ± 0.07 | 0.51 ± 0.06† |
| Rise time, ms | |||||
| Con | 3.53 ± 0.44 | 2.24 ± 0.25 | 3.37 ± 0.36 | 2.13 ± 0.25 | 3.82 ± 0.55 |
| CD | 3.65 ± 0.71 | 2.45 ± 0.41 | 3.71 ± 0.62 | 2.07 ± 0.34 | 3.73 ± 0.91 |
| Half-width, ms | |||||
| Con | 25.3 ± 4.8 | 13.9 ± 2.3 | 25.7 ± 3.9 | 12.8 ± 2.4 | 27.4 ± 3.5 |
| CD | 25.6 ± 6.1 | 14.2 ± 2.9 | 24.7 ± 5.5 | 13.4 ± 3.6 | 25.8 ± 4.7 |
| Latency, ms | |||||
| Con | 1.25 ± 0.20 | 0.99 ± 0.22 | 1.27 ± 0.24 | 1.07 ± 0.26 | 1.31 ± 0.21 |
| CD | 1.29 ± 0.23 | 1.04 ± 0.25 | 1.28 ± 0.19 | 1.11 ± 0.23 | 1.29 ± 0.20 |
Values are kinetic parameters of inhibitory (IPSPs) or excitatory postsynaptic potentials (EPSPs) in neuronal connections in control tissue (Con) or dysplastic cortex (CD). Connection rate is expressed as the number of connected pairs per total pairs [e.g., in the 81 recorded pairs of FS-PV interneurons (PV) and pyramid neurons from control, the connection rate of PV to pyramid was 27/81 (27 connected pairs) and that of pyramid to PV was 20/81 (20 connected pairs)], and numbers in parentheses show the connection rate as a percentage. In reciprocal chemical coupling in pairs of PV cells, the values for amplitude, failure rate, coefficient of variation (CV), rise time, half width, and latency (n = 44 in control and n = 11 in irradiated rats) are means ± SE and include the connections from cell 1 to cell 2 and from cell 2 to cell 1.
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↵* P < 0.05;
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↵† P < 0.01 vs. Con.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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