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Article: Increasing SK2 Channel Activity Impairs Associative Learning.

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McKay BM; Oh MM; Galvez R; Burgdorf J; Kroes RA; Weiss C; Adelman JP; Moskal JR; Disterhoft JF
J. Neurophysiol., 2012


Table 1.

Bath application of NS309 did not significantly affect the basic membrane properties of CA1 pyramidal neurons ex vivo

aCSFNS309
Vrest (mV)-65.1 ± 0.9-64.8 ± 1.2
Input resistance (MΩ)88.6 ± 2.383.5 ± 4.3
Sag (mV)3.22 ± 0.293.46 ± 0.42
sAHP (mV)-1.77 ± 0.25-1.61 ± 0.39
AP thresh (mV)-50.1 ± 1.5-51.5 ± 1.9
AP height (mV)94.2 ± 4.394.1 ± 2.7
AP half-width (ms)1.14 ± 0.061.05 ± 0.06
  • Values are means ± SE. Vrest is the resting membrane potential immediately after breaking into the cell. Input resistance is calculated as the slope of the current-voltage (I-V) curve. Sag is the difference between the peak and steady-state hyperpolarization in response to a -250 pA, 800-ms current injection. The sAHP was measured 1 s after the end of the last action potential in a five-spike train. Action potentials were elicited by a long depolarizing pulse sufficient to evoke a single action potential in 100 ms. Threshold was measured where the first derivative of the upslope of the trace equals 20 mV/ms. Height is the difference between the baseline and maximal depolarization. Half-width is width of the action potential at the midpoint between the maximal depolarization and the threshold. N = 9.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell slow AHP amplitude (mV) -1.77 ± 0.25 (9) 1.77 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -50.1 ± 1.5 (9) -50.1 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude from resting (mV) 94.2 ± 4.3 (9) 94.2 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -65.1 ± 0.9 (9) -65.1 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.14 ± 0.06 (9) 1.14 (ms) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 88.6 ± 2.3 (9) 88.6 (MΩ) Data Table
Hippocampus CA1 pyramidal cell sag amplitude (mV) 3.22 ± 0.29 (9) 3.22 (mV) Data Table