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Article: Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine.

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Guan D; Armstrong WE; Foehring RC
J. Neurophysiol., 2015


Table 6.

Effects of apamin and NE on repetitive firing

Firing Rate, 2 s, Hzf-I Slope, 200 ms, Hz/nAf-I Slope, 2 s, Hz/nA% AdaptationAdaptation Index
Etv1
    Control15 ± 3 (8)101 ± 9 (10)40 ± 12 (10)82 ± 3 (10)35 ± 11 (10)
    Apamin12 ± 2 (8)108 ± 14 (10)45 ± 13 (10)82 ± 5 (10)39 ± 7 (10)
    Control (NE)9 ± 2 (8)49 ± 8 (8)15 ± 5 (8)83 ± 2 (8)55 ± 11 (8)
    NE26 ± 4 (8)*81 ± 5 (8)*47 ± 3 (8)*59 ± 5 (8)*5 ± 2 (8)*
Glt
    Control26 ± 3 (8)160 ± 20 (10)140 ± 20 (10)18 ± 5 (10)0.6 ± 0.2 (10)
    Apamin37 ± 16 (8)*170 ± 20 (10)150 ± 20 (10)26 ± 5 (10)0.5 ± 0.1 (10)
    Control (NE)23 ± 2 (9)150 ± 7 (9)120 ± 10 (9)17 ± 3 (9)0.6 ± 0.2 (9)
    NE24 ± 2 (9)160 ± 7 (9)130 ± 7 (9)23 ± 5 (9)0.7 ± 0.2 (9)
  • Data are presented as means ± SE (n, number of cells). Firing was elicited in response to 2-s current injections at different amplitudes. Firing rate (2 s) is the average firing frequency over the entire 2-s current injection (in Hz). Percentage of adaptation = 100 × (frequency at 3rd ISI - frequency at steady state ISI/frequency at 3rd ISI). Adaptation index was for firing at 3× rheobase.

  • * Significant difference vs. control (P < 0.05, paired t-test). NE, norepinephrine.


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