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Article: Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Nenov MN; Tempia F; Denner L; Dineley KT; Laezza F J. Neurophysiol., 2015
Table 2.
Comparison between the number of action potentials, input resistance (Rin), and current threshold (Itrh) in type I and type II DG granule cells
| Wild-type | Tg2576 | Tg2576 + RSG | Wild-type + RSG | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type I, n = 19 | Type II, n = 8 | P < | Type I, n = 18 | Type II, n = 13 | P < | Type I, n = 26 | Type II, n = 11 | P < | Type I, n = 16 | Type II, n = 8 | P < | |
| # of APs at 90 pA current step | 14.1 ± 1.3 | 8.8 ± 0.9 | 0.005 | 13.4 ± 0.8 | 10.6 ± 0.9 | 0.05 | 14.5 ± 0.8 | 8.4 ± 0.6 | 0.005 | 14.25 ± 0.8 | 7.9 ± 1.1 | 0.005 |
| # of APs at 220 pA current step | 5.4 ± 0.8 | 17.3 ± 1.5 | 0.005 | 7.3 ± 0.9 | 21.2 ± 0.9 | 0.005 | 7 ± 0.9 | 17.9 ± 0.8 | 0.005 | 7.1 ± 0.9 | 16.5 ± 1.2 | 0.005 |
| Rin, MΩ | 443.3 ± 19.9 | 297.2 ± 13.6 | 0.005 | 419.1 ± 16.4 | 345.7 ± 14.9 | 0.005 | 440.6 ± 11.7 | 342.2 ± 22.4 | 0.005 | 444.5 ± 16.5 | 377.3 ± 12.9 | 0.005 |
| Itrh, pA | 25.3 ± 2.7 | 41.3 ± 5.5 | 0.05 | 30.6 ± 2.7 | 36.9 ± 4.3 | 0.2 | 26.9 ± 1.9 | 41.8 ± 2.9 | 0.01 | 30 ± 2 | 42.5 ± 6.5 | 0.05 |
Type I cells were compared with type II cells for wild-type, RSG-treated wild-type, Tg2576, or RSG-treated Tg2576. Data are mean ± SE. P values obtained with Student's t-test.
DG, dentate gyrus; APs, action potentials.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|