Article: Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Nenov MN; Tempia F; Denner L; Dineley KT; Laezza F
J. Neurophysiol., 2015

Table 4.

Comparison of firing, active, and passive properties of type I DG granule cells between wild-type and RSG-treated wild-type

DG GC Type I	Wild-type, n = 19	Wild-type + RSG, n = 16	P
MRP, mV	-59.6 ± 1.4	-61.9 ± 1.7	0.3
V_trh, mV	-48.6 ± 1.1	-44.9 ± 1.1	0.03^*
I_trh, mV	25.3 ± 2.7	30 ± 2	0.18
C_m, pF	62.3 ± 5.8	67.6 ± 3.6	0.46
R_in, MΩ	443.3 ± 19.9	444.5 ± 16.5	0.96
τ, ms	26.05 ± 1.5	29.9 ± 1.8	0.1
fAHP, mV	-11.8 ± 1.2	-12.4 ± 1.4	0.74
ADP, mV	3.9 ± 0.7	4.6 ± 0.6	0.47
sAHP, mV	-10.8 ± 1.05	-11.1 ± 1.1	0.85
Number of APs at Current Step of
20, pA	5 ± 0.9	3.3 ± 1.2	0.31
30, pA	7.3 ± 0.8	3.6 ± 0.6	0.002^*
40, pA	9.05 ± 0.9	5.9 ± 0.7	0.01^*
50, pA	10.7 ± 0.9	8.2 ± 0.7	0.04^*
60, pA	12.3 ± 1.02	10.2 ± 0.7	0.09
Instantaneous Firing Frequency (Hz) at Current Step of
50, pA	24.6 ± 2.3	18.1 ± 1.3	0.02^*
90, pA	39.4 ± 3.5	29.9 ± 1.6	0.02^*
110, pA	45.3 ± 3.9	34.6 ± 1.8	0.02^*
140, pA	54.4 ± 5.1	40.9 ± 2.2	0.02^*

Data are mean ± SE.
↵* P values obtained with Student's t-test.
GC, granule cell; fAHP, fast after-hyperpolarization; ADP, after-depolarization; sAHP, slow AHP.

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	resting membrane potential (mV)	-59.6 ± 1.4 (19)	-59.6 (mV)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	spike threshold (mV)	-48.6 ± 1.1 (19)	-48.6 (mV)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	cell capacitance (pF)	62.3 ± 5.8 (19)	62.3 (pF)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	input resistance (MΩ)	443.3 ± 19.9 (19)	443.3 (MΩ)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	membrane time constant (ms)	26.05 ± 1.5 (19)	26.05 (ms)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	fast AHP amplitude (mV)	-11.8 ± 1.2 (19)	11.8 (mV)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	ADP amplitude (mV)	3.9 ± 0.7 (19)	3.9 (mV)	Data Table
Dentate gyrus granule cell	Immature unsustained-firing dentate gyrus granule cells	slow AHP amplitude (mV)	-10.8 ± 1.05 (19)	10.8 (mV)	Data Table