|
Article: Altered dendritic complexity affects firing properties of cortical layer 2/3 pyramidal neurons in mice lacking the 5-HT3A receptor.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) van der Velden L; van Hooft JA; Chameau P J. Neurophysiol., 2012
Table 1.
Morphological and electrophysiological parameter comparisons between the 5-HT3A KO and WT neurons
| Parameters | WT | KO |
|---|---|---|
| Total dendritic length, μm | 1,095.3 ± 63.6 | 1,476.0 ± 69.2† |
| No. of endpoints | 15.6 ± 0.91 | 20,6 ± 0.99† |
| Sum of branch order | 83.8 ± 6.8 | 112.2 ± 8.2* |
| Input resistance, MΩ | 128.5 ± 12.0 | 118.4 ± 11.0 |
| Membrane time constant, ms | 14.9 ± 1.2 | 18.9 ± 1.1* |
| Cellular capacitance, pF | 120 ± 0.6 | 180 ± 1.2† |
| Resting potential, mV | -58.2 ± 1.9 | -66.9 ± 2.5† |
| First AP amplitude, mV | 82.4 ± 3.4 | 92.6 ± 1.6† |
| Sequential AP amplitude, mV | 71 ± 2.8 | 80.5 ± 1.7† |
| First AP half-width, ms | 1.15 ± 0.064 | 0.92 ± 0.027† |
| Sequential AP half-width, ms | 1.88 ± 0.16 | 1.38 ± 0.067† |
| AP threshold, mV | -30.87 ± 0.91 | -37.38 ± 0.80† |
| Rheobase, pA | 170.95 ± 16.85 | 146.67 ± 11.56 |
| AHP amplitude, mV | 10.3 ± 0.48 | 10.1 ± 0.53 |
| AHP slope, mV/ms | 0.19 ± 0.01 | 0.26 ± 0.016† |
| Normalized AHP slope | 0.79 ± 0.024 | 0.87 ± 0.013† |
| Normalized AHP amplitude | 0.975 ± 0.017 | 0.959 ± 0.012 |
Values are means ± SE for wild-type (WT; n = 21) and 5-HT3A receptor knockout (KO; n = 24) neurons. AP, action potential; AHP, afterhyperpolarization.
↵* P < 0.05 and †P < 0.01.