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Article: Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.

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Liu Y; Harding M; Pittman A; Dore J; Striessnig J; Rajadhyaksha A; Chen X
J. Neurophysiol., 2014


Table 1.

Basic electrophysiological properties of dopaminergic cells in wild type (WT), Cav1.2DHP-/- and Cav1.3-/- mice

wild type (WT)1Cav1.2DHP-/-2Cav1.3-/-3P1,2P1,3
Number of spontaneously active cells18 of 31, 58.1%32 of 50, 64.0%7 of 26, 26.9%>0.05<0.05
Resting membrane potentials (mV)-52.69 ± 1.17-51.98 ± 1.03-52.13 ± 1.18>0.05>0.05
Basal firing frequencies (Hz)0.68 ± 0.200.72 ± 0.110.25 ± 0.07>0.05<0.05
Spike amplitude (mV)58.00 ± 2.3958.13 ± 2.0954.62 ± 2.31>0.05>0.05
Firing threshold (mV)-38.91 ± 0.76-38.87 ± 0.88-41.03 ± 1.71>0.05>0.05
Spike half-width (ms)2.97 ± 0.113.01 ± 0.152.97 ± 0.20>0.05>0.05
Hyperpolarizing afterpotentials (mV)-13.20 ± 1.57-13.57 ± 1.30-13.81 ± 1.51>0.05>0.05
Hyperpolarization following an application of 50 μM dopamine (mV)-9.01 ± 1.02-9.46 ± 1.00-7.96 ± 1.07>0.05>0.05
Ih sag (mV)20.98 ± 1.1720.09 ± 1.1019.20 ± 1.00>0.05>0.05

  • Values are means ± SE.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron spontaneous firing rate (Hz) 0.68 ± 0.2 0.68 (Hz) Data Table
Ventral tegmental area dopamine neuron spike amplitude (mV) 58.0 ± 2.39 58.0 (mV) Data Table
Ventral tegmental area dopamine neuron spike threshold (mV) -38.91 ± 0.76 -38.91 (mV) Data Table
Ventral tegmental area dopamine neuron spike half-width (ms) 2.97 ± 0.11 2.97 (ms) Data Table
Ventral tegmental area dopamine neuron sag amplitude (mV) 20.98 ± 1.17 20.98 (mV) Data Table
Ventral tegmental area dopamine neuron resting membrane potential (mV) -52.69 ± 1.17 -52.69 (mV) Data Table