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Article: Electrophysiological classes of layer 2/3 pyramidal cells in monkey prefrontal cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Zaitsev AV; Povysheva NV; Gonzalez-Burgos G; Lewis DA J. Neurophysiol., 2012
Table 1.
Electrophysiological characteristics of pyramidal cells from different clusters
| Characteristics | RS_LRi | RS_HRi | IM | LTS | F Ratio | P Value | Fisher's LSD |
|---|---|---|---|---|---|---|---|
| RMP, mV | -73.2 ± 1.1 | -71.3 ± 1.9 | -71.8 ± 1.0 | -71.7 ± 1.1 | 0.5 | 0.70 | (1,2,3,4) |
| Rin, MΩ | 174 ± 16 | 332 ± 28 | 118 ± 7 | 261 ± 42 | 18.1 | <0.001 | (3); (1); (2,4) |
| τ, ms | 19.6 ± 0.9 | 20.8 ± 2.3 | 17.2 ± 0.7 | 25.3 ± 3.0 | 4.5 | <0.01 | (1,2,3); (2,4) |
| I0, pA | 106 ± 8 | 52 ± 9 | 120 ± 7 | 60 ± 12 | 12.8 | <0.001 | (2,4); (1,3) |
| Sag, % | 9.7 ± 1.2 | 6.6 ± 0.9 | 20.2 ± 2.6 | 13.2 ± 2.0 | 9.1 | <0.001 | (1,2,4); (3) |
| RD, % | 8.9 ± 1.4 | 7.3 ± 0.9 | 19.0 ± 2.0 | 14.8 ± 2.4 | 8.8 | <0.001 | (1,2); (3; 4) |
| Hump, %) | 11.8 ± 1.9 | 8.6 ± 2.3 | 31.2 ± 3.7 | 32.3 ± 4.6 | 14.2 | <0.001 | (1,2); (3; 4) |
| TFS, ms | 136 ± 10 | 150 ± 20 | 117 ± 8 | 126 ± 17 | 1.2 | 0.31 | (1,2,3,4) |
| APT, mV | -40.4 ± 0.9 | -40.0 ± 0.9 | -41.4 ± 0.7 | -44 ± 0.8 | 3.1 | <0.05 | (1,2,3); (3,4) |
| APA, mV | 82 ± 2 | 64 ± 4 | 82 ± 2 | 78 ± 2 | 10.9 | <0.001 | (2); (1,3,4) |
| APD, ms | 0.93 ± 0.02 | 0.88 ± 0.04 | 0.90 ± 0.03 | 1.12 ± 0.11 | 3.3 | <0.05 | (1,2,3); (4) |
| AHP, mV | 11.9 ± 0.8 | 9.6 ± 1.0 | 10.4 ± 0.6 | 6.6 ± 1.0 | 5.9 | <0.01 | (4); (1,2,3) |
| fAHP, mV | 7.2 ± 1.5 | 5.5 ± 1.7 | 5.5 ± 1.1 | 6.0 ± 1.0 | 0.40 | 0.75 | (1,2,3,4) |
| ADP, mV | 0.84 ± 0.21 | 0.52 ± 0.28 | 2.4 ± 0.35 | n/a | 6.7 | <0.001 | (1,2); (3) |
| mAHP, mV | 5.5 ± 0.7 | 4.6 ± 0.9 | 7.3 ± 0.6 | n/a | 10.1 | <0.001 | (1,2); (3) |
| tAHP, ms | 37 ± 4 | 32 ± 6 | 61 ± 6 | 1.3 ± 0.2 | 19.8 | <0.001 | (4); (1,2); (3) |
| f1_k, Hz/pA | 0.42 ± 0.04 | 1.22 ± 0.15 | 0.70 ± 0.06 | 0.49 ± 0.07 | 19.4 | <0.001 | (1,4); (3,4); (2) |
| f1_threshold, Hz | 1.1 ± 1.2 | 1.0 ± 5.4 | 16.8 ± 7.7 | 102 ± 15 | 34.1 | <0.001 | (1,2,3); (4) |
| f2_k, Hz/pA | 0.25 ± 0.03 | 0.92 ± 0.17 | 0.33 ± 0.05 | 0.55 ± 0.07 | 14.6 | <0.001 | (1,3); (3,4); (2) |
| f2_threshold, Hz | 1.67 ± 0.65 | 0.52 ± 2.17 | -1.1 ± 1.1 | 39 ± 10 | 23.5 | <0.001 | (1,2,3); (4) |
| ISI1-2, ms | 215 ± 13 | 165 ± 28 | 186 ± 24 | 27 ± 15 | 13.2 | <0.001 | (4); (1,2,3) |
| FFAI, % | 37 ± 2 | 37 ± 5 | 66 ± 3 | 42 ± 3 | 21.7 | <0.001 | (1,2,4); (3) |
| FFAL, % | 50 ± 2 | 58 ± 5 | 76 ± 2 | 86 ± 2 | 34.4 | <0.001 | (1,2); (3); (4) |
| fss, Hz | 16.3 ± 0.7 | 26.6 ± 2.4 | 17.1 ± 0.9 | 16.5 ± 1.0 | 13.9 | <0.001 | (1,3,4); (2) |
Values are means ± SE of electrophysiological measurements in regular-spiking cells with low (RS_LRi; cluster 1; n = 27) and high input resistance (RS_HRi; cluster 2; n = 13), intermediate-spiking cells (IM; cluster 3; n = 24), and low-threshold-spiking cells (LTS; cluster 4; n = 13). See text for definition of electrophysiological characteristics. Following cluster analysis, Fisher's post hoc least significant difference (LSD) test was applied to compare the means for any pair of clusters 1-4 with statistically distinct properties; cluster numbers grouped within parentheses for a measurement indicate no significant difference between the indicated clusters, whereas different sets of parentheses for each measurement indicate significant differences between cells in each respective group of clusters.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | input resistance (MΩ) | 174.0 ± 16.0 (27) | 174.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | fast AHP amplitude (mV) | 5.5 ± 1.1 (24) | 5.5 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | fast AHP amplitude (mV) | 6.0 ± 1.0 (13) | 6.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | ADP amplitude (mV) | 0.84 ± 0.21 (27) | 0.84 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | ADP amplitude (mV) | 0.52 ± 0.28 (13) | 0.52 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | ADP amplitude (mV) | 2.4 ± 0.35 (24) | 2.4 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | input resistance (MΩ) | 332.0 ± 28.0 (13) | 332.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | medium AHP amplitude (mV) | 5.5 ± 0.7 (27) | 5.5 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | medium AHP amplitude (mV) | 4.6 ± 0.9 (13) | 4.6 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | medium AHP amplitude (mV) | 7.3 ± 0.6 (24) | 7.3 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | input resistance (MΩ) | 118.0 ± 7.0 (24) | 118.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | AHP duration (ms) | 37.0 ± 4.0 (27) | 37.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | AHP duration (ms) | 32.0 ± 6.0 (13) | 32.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | AHP duration (ms) | 61.0 ± 6.0 (24) | 61.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | AHP duration (ms) | 1.3 ± 0.2 (13) | 1.3 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | input resistance (MΩ) | 261.0 ± 42.0 (13) | 261.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | FI slope (Hz/pA) | 0.42 ± 0.04 (27) | 420.0 (Hz/nA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | FI slope (Hz/pA) | 1.22 ± 0.15 (13) | 1220.0 (Hz/nA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | FI slope (Hz/pA) | 0.7 ± 0.06 (24) | 700.0 (Hz/nA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | FI slope (Hz/pA) | 0.49 ± 0.07 (13) | 490.0 (Hz/nA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | adaptation ratio (other) | 50.0 ± 2.0 (27) | 50.0 (None) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | adaptation ratio (other) | 58.0 ± 5.0 (13) | 58.0 (None) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | membrane time constant (ms) | 19.6 ± 0.9 (27) | 19.6 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | adaptation ratio (other) | 76.0 ± 2.0 (24) | 76.0 (None) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | adaptation ratio (other) | 86.0 ± 2.0 (13) | 86.0 (None) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | firing frequency (Hz) | 16.3 ± 0.7 (27) | 16.3 (Hz) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | firing frequency (Hz) | 26.6 ± 2.4 (13) | 26.6 (Hz) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | firing frequency (Hz) | 17.1 ± 0.9 (24) | 17.1 (Hz) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | firing frequency (Hz) | 16.5 ± 1.0 (13) | 16.5 (Hz) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | membrane time constant (ms) | 20.8 ± 2.3 (13) | 20.8 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | resting membrane potential (mV) | -73.2 ± 1.1 (27) | -73.2 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | membrane time constant (ms) | 17.2 ± 0.7 (24) | 17.2 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | membrane time constant (ms) | 25.3 ± 3.0 (13) | 25.3 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | rheobase (pA) | 106.0 ± 8.0 (27) | 106.0 (pA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | rheobase (pA) | 52.0 ± 9.0 (13) | 52.0 (pA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | rheobase (pA) | 120.0 ± 7.0 (24) | 120.0 (pA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | rheobase (pA) | 60.0 ± 12.0 (13) | 60.0 (pA) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | resting membrane potential (mV) | -71.3 ± 1.9 (13) | -71.3 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | sag ratio | 9.7 ± 1.2 (27) | 0.097 (ratio) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | sag ratio | 6.6 ± 0.9 (13) | 0.066 (ratio) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | sag ratio | 20.2 ± 2.6 (24) | 0.202 (ratio) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | sag ratio | 13.2 ± 2.0 (13) | 0.132 (ratio) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | resting membrane potential (mV) | -71.8 ± 1.0 (24) | -71.8 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | resting membrane potential (mV) | -71.7 ± 1.1 (13) | -71.7 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | first spike latency (ms) | 136.0 ± 10.0 (27) | 136.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | first spike latency (ms) | 150.0 ± 20.0 (13) | 150.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | first spike latency (ms) | 117.0 ± 8.0 (24) | 117.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | first spike latency (ms) | 126.0 ± 17.0 (13) | 126.0 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | spike threshold (mV) | -40.4 ± 0.9 (27) | -40.4 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | spike threshold (mV) | -40.0 ± 0.9 (13) | -40.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | spike threshold (mV) | -41.4 ± 0.7 (24) | -41.4 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | spike threshold (mV) | -44.0 ± 0.8 (13) | -44.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | spike amplitude (mV) | 82.0 ± 2.0 (27) | 82.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | spike amplitude (mV) | 64.0 ± 4.0 (13) | 64.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | spike amplitude (mV) | 82.0 ± 2.0 (24) | 82.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | spike amplitude (mV) | 78.0 ± 2.0 (13) | 78.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | spike half-width (ms) | 0.93 ± 0.02 (27) | 0.93 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | spike half-width (ms) | 0.88 ± 0.04 (13) | 0.88 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | spike half-width (ms) | 0.9 ± 0.03 (24) | 0.9 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | spike half-width (ms) | 1.12 ± 0.11 (13) | 1.12 (ms) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | AHP amplitude (mV) | 11.9 ± 0.8 (27) | 11.9 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | AHP amplitude (mV) | 9.6 ± 1.0 (13) | 9.6 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 intermediate spiking supragranular pyramidal cells | AHP amplitude (mV) | 10.4 ± 0.6 (24) | 10.4 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 low threshold spiking supragranular pyramidal cells | AHP amplitude (mV) | 6.6 ± 1.0 (13) | 6.6 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking low input resistance supragranular pyramidal cells | fast AHP amplitude (mV) | 7.2 ± 1.5 (27) | 7.2 (mV) | Data Table |
| Neocortex pyramidal cell layer 2-3 | Dorsolateral prefrontal cortex layer 2/3 regular spiking high input resistance supragranular pyramidal cells | fast AHP amplitude (mV) | 5.5 ± 1.7 (13) | 5.5 (mV) | Data Table |