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Article: Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) McCutcheon JE; Conrad KL; Carr SB; Ford KA; McGehee DS; Marinelli M J. Neurophysiol., 2012
Table 1.
Electrophysiological properties of VTA dopamine neurons recorded under chloral hydrate anesthesia in adolescent and adult rats
| Adolescent | Adult | P Value | |
|---|---|---|---|
| Overall activity | |||
| Firing rate, Hz | 4.89 ± 0.26 (54) | 3.43 ± 0.25 (38) | <0.001‡ |
| Nonbursting firing rate, Hz | 4.73 ± 0.24 (54) | 3.66 ± 0.24 (38) | 0.003† |
| CV of firing rate | 0.62 ± 0.05 (54) | 0.79 ± 0.06 (38) | 0.032* |
| Amount of bursting | |||
| Spikes in burst, % | 22.72 ± 3.51 (54) | 27.62 ± 4.24 (38) | 0.375 |
| Time spent bursting, % | 7.44 ± 1.36 (54) | 5.10 ± 1.30 (38) | 0.232 |
| Burst event frequency, Hz | 0.34 ± 0.05 (54) | 0.36 ± 0.06 (38) | 0.826 |
| Interburst interval, s | 14.54 ± 4.15 (51) | 6.65 ± 1.48 (32) | 0.136 |
| Characteristics of bursts | |||
| No. of spikes per burst | 3.25 ± 0.19 (51) | 2.70 ± 0.11 (34) | 0.031* |
| Burst duration, ms | 179.86 ± 19.31 (51) | 113.83 ± 10.75 (34) | 0.011* |
| Intraburst frequency, Hz | 15.79 ± 0.67 (51) | 18.94 ± 1.18 (34) | 0.015* |
| Burst ISI, ms | 71.79 ± 2.19 (51) | 61.30 ± 2.62 (34) | 0.003† |
| ISI of first two spikes, ms | 61.01 ± 1.59 (51) | 54.40 ± 1.86 (34) | 0.009* |
| Postburst interval, ms | 390.49 ± 32.10 (51) | 606.67 ± 66.68 (34) | 0.002† |
↵Values are means ± SE with n (no. of cells) in parentheses. P values after 2-tailed Student's t-test are given for adolescent vs. adult rats for each parameter (*P ≤ 0.05; †P ≤ 0.01; ‡P ≤ 0.001). CV, coefficient of variation; ISI, interspike interval; VTA, ventral tegmental area.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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