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Article: Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Abbasi S; Kumar SS J. Neurophysiol., 2014
Table 1.
Action potential waveform properties of PrS neurons
| Electrophysiological Parameter | IR-Con (n = 15) | IR-Epi (n = 5) | FA-Con (n = 12) | FA-Epi (n = 4) | RS-Con (n = 116) | RS-Epi (n = 43) |
|---|---|---|---|---|---|---|
| Resting membrane potential, mV | -69 ± 1 | -69 ± 2 | -62 ± 1 | -63 ± 3 | -66 ± 1 | -66 ± 1 |
| Spike firing threshold, mV | -41 ± 1 | -41 ± 1 | -40 ± 1 | -42 ± 2 | -40 ± 1 | -39 ± 1 |
| Early spike frequency adaptation, % | 47 ± 6 | 60 ± 7 | 57 ± 4 | 61 ± 3 | 40 ± 2 | 51 ± 2 |
| RS-Epi >> RS-Con | ||||||
| Late spike frequency adaptation, % | 25 ± 5 | 18 ± 5 | n/d | n/d | 8 ± 1 | 6 ± 1 |
| RS-Con > RS-Epi | ||||||
| Delay, ms | 35 ± 3 | 32 ± 8 | 13 ± 2 | 16 ± 7 | 25 ± 1 | 28 ± 7 |
| Accommodative hump, mV | 1.4 ± 0.4 | 1.0 ± 0.2 | 3.3 ± 0.9 | 0.8 ± 0.1 | 2.2 ± 0.2 | 2.3 ± 0.3 |
| Half-width, ms | 2.8 ± 0.2 | 2.2 ± 0.1 | 2.5 ± 0.3 | 2.1 ± 0.3 | 2.2 ± 0.1 | 1.8± 0.1 |
| RS-Con >> RS-Epi | ||||||
| Input resistance, MΩ | 264 ± 22 | 196 ± 16 | 341 ± 35 | 166 ± 17 | 330 ± 8 | 306 ± 15 |
| FA-Con > FA-Epi | ||||||
| Sag ratio, % | 1.8 ± 0.2 | 3.5 ± 1.8 | 1.9 ± 0.6 | 0.7 ± 0.4 | 2.2 ± 0.2 | 4.7 ± 0.8 |
| RS-Epi >> RS-Con | ||||||
| Maximum frequency, Hz | 13 ± 1.8 | 22 ± 4.1 | 39 ± 4.5 | 24 ± 4.4 | 35 ± 1.7 | 43 ± 3.1 |
| RS-Epi > RS-Con | ||||||
| Instantaneous firing frequency, Hz | 9 ± 1.0 | 13 ± 1.5 | 24 ± 3.2 | 15 ± 2.7 | 24 ± 0.9 | 26 ± 1.4 |
| Steady-state firing frequency, Hz | 4 ± 0.5 | 6 ± 0.7 | n/d | n/d | 16 ± 0.7 | 17 ± 0.9 |
| SD of steady-state firing frequency, Hz | 1.7 ± 0.2 | 2.3 ± 0.4 | n/d | n/d | 1.1 ± 0.1 | 1.1 ± 0.1 |
Values represent means ± SE; n, number of cells. PrS, presubiculum; Con, control group; Epi, epileptic group; RS, regular-spiking cell; IR, irregular-spiking cell; FA, fast-adapting cell. Electrophysiological parameters were measured as described in materials and methods. Significant differences between Epi and Con groups are italicized. >, significantly greater with P < 0.05, t-test; >>, significantly greater, with P < 0.01, t-test; n/d, not determined because number of action potentials was insufficient for reliable analysis.