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Article: Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.

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Jiang R; Diaz-Castro B; Looger LL; Khakh BS
J. Neurosci., 2016


Table 2.

TBOA has a greater effect on astrocyte basal iGluSnFR signals in WT mice than in R6/2 mice

Baseline dF/F + TBOA dF/F p Fold-change from baseline to TBOA n (cells, mice)
WT 0.01 ± 0.01 0.39 ± 0.04 <0.00001 39.8 ± 10.2 19, 4
R6/2 0.03 ± 0.01 0.16 ± 0.03 <0.00001 7.7 ± 2.5 24, 4

  • Data are from experiments such as those illustrated in Figure 7B, but summarized here for R6/2 and noncarrier controls (WT). TBOA significantly increased the iGluSnFR signals in WT and R6/2 mice, but the fold changes were significantly greater in WT (p < 0.00001). The mean values for fold changes calculated from individual experiments are shown.


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