Article: Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Brickley SG; Revilla V; Cull-Candy SG; Wisden W; Farrant M Nature, 2001
Wild-type | a6 -/- | |
---|---|---|
Membrane properties | ||
Resting potential (mV) | -78.2 ± 0.9 | -75.5 ± 1.1 |
Input conductance (nS) | 1.1 ± 0.1 | 0.8 ± 0.1 |
Action potentials | ||
Threshold (mV) | -34.7 ± 1.1 | -34.0 ± 1.4 |
Amplitude (mV) | 81.2 ± 1.5 | 79.9 ± 1.8 |
10±90% rise time (μs) | 223 ± 8 | 215 ± 7 |
Half-width (μs) | 434 ± 12 | 425 ± 10 |
Peak after hyperpolarization (mV) | -67.4 ± 0.8 | -67.1 ± 1.5 |
Action potential threshold current (pA) | 25.3 ± 2.7 | 26.2 ± 6.0 |
Action potential frequency at +40 pA (Hz) | 35.8 ± 9.4 | 36.1 ± 11.3 |
Action potential frequency versus current (Hz/pA) | 1.89 | 1.71 |
All values are mean +\- s.e.m. Resting membrane potential (zero current potential) was measured within 1 min of establishing whole-cell recording. Input conductance was measured from the steady-state voltage response to a -2 pA current injection. Membrane and action potential properties were determined from 25 wild-type and 26 a6 -/- GCs (except for action potential frequency at +40 pA and action potential frequency versus current, where n = 5 and 13, respectively). EPSCs were recorded from five wild-type and four a6 -/- GCs. EPSPs were from seven wild-type and six a6 -/- GCs.: |