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Article: Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome.

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Usowicz MM; Garden CL
Brain Res., 2012


Table 1: Properties of cerebellar granule cells from wild-type and Ts65Dn mice, curated from text and figures of paper.
wild-type Ts65Dn mice
input capacitance (pF) 3 (48) 3.8 (40)
resting membrane potential (mV) −80.0 ± 0.3 (38) −79.7 ± 0.5 (21)
AP voltage threshold (mV) −47.8 (37) −47.8 (20)
first spike latency (ms) 182.9 ± 18.7 (33) 181.9 ± 19.9 (20)
AP amplitude, peak to trough (mV) 99.4 ± 1.4 (33) 103.8 ± 1.1 (20)
AP amplitude, threshold to peak (mV) 75.2 ± 1.4 (33) 79.6 ± 1.1 (20)
AP half-width (μs) 714.9 ± 25.9 (33) 643.5 ± 15.4 (20)
AP overshoot (mV) 27.5 32
AHP voltage (mV) -72 -72
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum granule cell first spike latency (ms) 182.9 ± 18.7 (33) 182.9 (ms) Data Table
Cerebellum granule cell spike amplitude from trough (mV) 99.4 ± 1.4 (33) 99.4 (mV) Data Table
Cerebellum granule cell spike amplitude (mV) 75.2 ± 1.4 (33) 75.2 (mV) Data Table
Cerebellum granule cell cell capacitance (pF) 3.0 (48) 3.0 (pF) Data Table
Cerebellum granule cell spike half-width (μs) 714.9 ± 25.9 (33) 0.7149 (ms) Data Table
Cerebellum granule cell spike peak (mV) 27.5 27.5 (mV) Data Table
Cerebellum granule cell AHP voltage (mV) -72.0 -72.0 (mV) Data Table
Cerebellum granule cell resting membrane potential (mV) -80.0 ± 0.3 (38) -80.0 (mV) Data Table
Cerebellum granule cell spike threshold (mV) -47.8 (37) -47.8 (mV) Data Table