Article: Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.

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Fan J; Stemkowski PL; Gandini MA; Black SA; Zhang Z; Souza IA; Chen L; Zamponi GW
Front Cell Neurosci, 2016

Table 1

Electrophysiological properties of hippocampal neurons in wild type (WT) and prion protein (PrP)-null mice.

	E_m (mV)	R_in (MΩ) (mV)	AP_amplitude (ms)	AP_half-width (mV/ms)	dV/dt_max (mV/ms)	rV/rt_max (mV)	Threshold
WT	-55 ± 1.4 (5)	256 ± 35.6 (8)	107 ± 6.6 (5)	1.9 ± 0.2 (5)	132 ± 23.5 (5)	-67 ± 6.2 (5)	-42 ± 2.0 (5)
PrP^-/-	-54 ± 1.3 (9)	361 ± 24.8 (11)	116 ± 2.3 (9)	1.8 ± 0.1 (9)	136 ± 13.8 (9)	-76 ± 7.9 (9)	-39 ± 2.6 (9)

Electrophysiological parameters were measured using whole-cell voltage clamp and current clamp recordings as described in “Materials and Methods” Section. Numbers of cells testes are shown in parentheses.

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Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Hippocampus CA1 pyramidal cell	resting membrane potential (mV)	-55.0 ± 1.4 (5)	-55.0 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance	256.0 ± 35.6 (8)	256.0 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	spike amplitude (ms)	107.0 ± 6.6 (5)	--	Data Table
Hippocampus CA1 pyramidal cell	spike half-width (mV/ms)	1.9 ± 0.2 (5)	--	Data Table
Hippocampus CA1 pyramidal cell	spike max rise slope (mV/ms)	132.0 ± 23.5 (5)	132.0 (mV/ms)	Data Table
Hippocampus CA1 pyramidal cell	spike max decay slope (mV)	-67.0 ± 6.2 (5)	--	Data Table
Hippocampus CA1 pyramidal cell	spike threshold	-42.0 ± 2.0 (5)	-42.0 (mV)	Data Table