Article: Serum S100B Is Related to Illness Duration and Clinical Symptoms in Schizophrenia-A Meta-Regression Analysis.
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Schümberg K; Polyakova M; Steiner J; Schroeter ML
Front Cell Neurosci, 2016
Study characteristics for the 19 studies included in the final meta-analysis.
| Reference |
Sample size |
Patient age (years; mean ± SD) |
Illness duration (years; mean ± SD) |
Serum S100B (ng/l; mean ± SD) |
Male-to-female ratio for patients |
PANSS score |
BPRS |
Bias rating |
|
P |
Co |
|
|
P |
Co |
|
Total |
Positive |
Negative |
General |
|
|
| Gattaz et al. (2000) |
23 |
23 |
36.0 ± 9.0 |
17.0 ± 7.0 |
440.0 ± 270.0 |
550.0 ± 140.0 |
2.3 |
|
|
|
|
15.8 ± 15.4 |
13 |
| Ryoun Kim et al. (2007) |
60 |
30 |
37.0 ± 3.5 |
15.0 ± 6.7 |
140.0 ± 91.7 |
78.0 ± 47.0 |
0.8 |
|
|
|
|
|
13 |
| Lara et al. (2001) |
20 |
20 |
31.0 ± 8.0 |
9.0 ± 7.0 |
120.0 ± 140.0 |
66.0 ± 67.0 |
1.9 |
107.0 ± 29.0 |
24.0 ± 9.0 |
29.0 ± 7.0 |
54.0 |
|
14 |
| Ling et al. (2007) |
57 |
60 |
33.5 ± 11.4 |
8.0 ± 9.0 |
119.0 ± 59.0 |
67.0 ± 22.0 |
0.9 |
77.8 ± 13.8 |
|
20.0 ± 6.8 |
|
|
14 |
| O’Connell et al. (2013) |
97 |
27 |
42.5 ± 12.2 |
Only clozapine duration stated |
79.5 ± 39.8 |
67.8 ± 20.8 |
2.3 |
|
|
|
|
31.0 ± 9.0 |
14 |
| Qi et al. (2009) |
63 |
50 |
50.8 ± 6.8 |
25.4 ± 7.2 |
359.0 ± 116.0 |
123.0 ± 50.0 |
2.2 |
59.8 ± 13.1 |
13.2 ± 6.1 |
20 ± 6.2 |
26.5 ± 5.5 |
|
18 |
| Rothermundt et al. (2001) |
26 |
26 |
37.0 ± 12.9 |
10.0 ± 10.4 |
98.0 ± 76.0 |
34.0 ± 17.5 |
0.6 |
86.7 ± 17.9 |
25 ± 6.3 |
19.5 ± 8.3 |
42.1 ± 9.6 |
|
16 |
| Rothermundt et al. (2004a) |
21 |
21 |
32.5 ± 13.0 |
|
65.0 ± 31.0 |
38.0 ± 8.0 |
4.3 |
97.7 ± 25.6 |
|
|
|
|
13 |
| Rothermundt et al. (2004b) |
98 |
98 |
42.1 ± 11.1 |
|
73.0 ± 32.0 |
44.0 ± 15.0 |
1.3 |
82.5 ± 17.1 |
14.8 ± 5.2 |
27.3 ± 5.3 |
40.3 ± 10.6 |
|
16 |
| Rothermundt et al. (2007) |
12 |
12 |
25.3 ± 4.8 |
1.9 ± 1.4 |
85.0 ± 70.0 |
38.0 ± 8.0 |
11 |
81.2 ± 20.1 |
19.3 ± 7.4 |
19.6 ± 7.8 |
42.4 ± 11.1 |
|
18 |
| Sarandol et al. (2007) |
40 |
35 |
34.0 ± 9.9 |
6.7 ± 6.4 |
46.1 ± 43.6 |
23.6 ± 14.9 |
0.8 |
|
|
|
|
21.0 ± 6.1 |
15 |
| Schmitt et al. (2005) |
41 |
23 |
63.3 ± 7.0 |
35.3 ± 11.4 |
132.2 ± 43.0 |
61.0 ± 26.0 |
1.4 |
|
|
|
|
46.2 ± 14.9 |
16 |
| Schroeter et al. (2003) |
30 |
15 |
34.8 ± 12.4 |
8.9 ± 8.8 |
180.3 ± 129.5 |
112.8 ± 53.4 |
0.9 |
|
|
|
|
45.3 ± 12.6 |
12 |
| Schroeter et al. (2009) |
20 |
19 |
34.6 ± 12.7 |
8.4 ± 9.6 |
73.4 ± 72.1 |
42.1 ± 69.7 |
0.8 |
|
|
|
|
47.6 ± 11.9 |
15 |
| Steiner et al. (2006) |
12 |
17 |
24.0 ± 7.0 |
0.4 ± 0.2 |
90.0 ± 30.0 |
80.0 ± 20.0 |
0.7 |
87.0 ± 15.0 |
24.0 ± 6.0 |
21.0 ± 6.0 |
42.0 ± 8.0 |
|
14 |
| Steiner et al. (2009) |
26 |
32 |
34.7 ± 11.3 |
8.0 ± 9.0 |
72.0 ± 38.0 |
52.0 ± 18.0 |
1.9 |
84.8 ± 11.2 |
20.1 ± 4.9 |
22.1 ± 6.5 |
42.7 ± 5.6 |
|
16 |
| Uzbay et al. (2013) |
18 |
19 |
37.4 ± 12.6 |
9.8 ± 10.11 |
7.8 ± 10.6 |
6.3 ± 7.8 |
1.6 |
87.2 ± 13.3 |
|
|
|
|
16 |
| Wiesmann et al. (1999) |
20 |
20 |
35.7 ± 10.7 |
8.0 ± 5.0 |
165.0 ± 138.0 |
54.0 ± 31.0 |
0.7 |
|
|
|
|
|
16 |
| Zhang et al. (2010) |
82 |
60 |
50.9 ± 7.2 |
26.6 ± 8.7 |
445.3 ± 196.0 |
122.0 ± 76.0 |
2.3 |
58.4 ± 13.2 |
12.2 ± 5.9 |
19.9 ± 6.5 |
26.2 ± 5.4 |
|
18 |
| Total study population |
766 |
607 |
37.8 ± 9.2 |
12.4 ± 9.4 |
146.9 ± 126.9 |
88.4 ± 119.7 |
2.0 ± 2.4 |
82.3 ± 14.2 |
19.1 ± 5.1 |
22.0 ± 3.6 |
39.3 ± 6.3 |
34.5 ± 13.9 |
15.1 ± 1.8 |
Note: BPRS, Brief Psychiatric Rating Scale; Co, control subjects; P, patients; PANSS, Positive And Negative Syndrome Scale; SD, standard deviation.
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |
