Article: Developmental Profile of Ion Channel Specializations in the Avian Nucleus Magnocellularis.
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Hong H; Rollman L; Feinstein B; Sanchez JT
Front Cell Neurosci, 2016
Change in potassium channel properties with different blockers.
|
E10–E12 |
E14–E16 |
E19–E21 |
ANOVA P |
| Percentage change in Kv current (Ik) with bath application of Flx∧ (%) |
| Ik reduction at -50 mV |
19.74 ± 23.03 (10) |
22.55 ± 16.65 (11) |
38.46 ± 20.96 (10) |
P = 0.11 (Figure 7G) |
| Ik reduction at -10 mV |
66.64 ± 18.40 (10) |
38.81 ± 15.37 (11) |
42.66 ± 18.48 (10) |
P < 0.01 (Figure 7F) |
| Ik reduction at +20 mV |
84.56 ± 11.35 (10) |
63.88 ± 11.10 (11) |
50.84 ± 16.80 (10) |
P < 0.001 (Figure 7E) |
| Percentage change in action potential (AP) properties with bath application of TEA* (%) |
| AP half width increase |
178.90 ± 143.30 (9) |
67.27 ± 22.53 (12) |
45.41 ± 39.40 (20) |
P < 0.0001 (Figure 9B) |
| Max fall rate reduction |
66.73 ± 10.69 (9) |
46.51 ± 10.92 (12) |
37.98 ± 17.08 (20) |
P < 0.001 (Figure 9C) |
| Threshold current reduction |
41.41 ± 24.45 (9) |
33.68 ± 10.01 (12) |
21.97 ± 11.49 (20) |
P < 0.01 (Figure 9D) |
Flx∧, Fluoxetine (100 μM), Kv3.1-containing KHVA+ channel blocker. TEA*, Tetraethylammonium (1 mM), Kv3.1–3.4 blocker.
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
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