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Article: Reg-2, A Downstream Signaling Protein in the Ciliary Neurotrophic Factor Survival Pathway, Alleviates Experimental Autoimmune Encephalomyelitis.

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Jiang H; Tian KW; Zhang F; Wang B; Han S
Front Neuroanat, 2016


CNTF treatment and Reg-2 treatment reduce c-SEP latency and increase c-SEP amplitude at 2 weeks post-immunization.

2 weeks
Latency (ms)
Groups N P Wave amplitude (μV mean ± SD)
Normal 15.53 ± 1.48** 20.45 ± 2.33** 1.22 ± 0.25**
EAE 26.91 ± 3.32 35.73 ± 3.54 0.39 ± 0.03
CNTF 21.35 ± 1.17* 27.1 ± 0.77* 0.72 ± 0.16*
Reg-2 18.2 ± 0.71* 24.78 ± 0.77* 0.65 ± 0.19*

*P < 0.05 vs. vehicle-treated EAE rats. **P < 0.01 vs. vehicle-treated EAE rats. N, negative deflection; P, positive deflection.


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