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Article: Reg-2, A Downstream Signaling Protein in the Ciliary Neurotrophic Factor Survival Pathway, Alleviates Experimental Autoimmune Encephalomyelitis.

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Jiang H; Tian KW; Zhang F; Wang B; Han S
Front Neuroanat, 2016


CNTF treatment and Reg-2 treatment reduce c-SEP latency and increase c-SEP amplitude at 8 weeks post-immunization.

8 weeks
Latency (ms)
Groups N P Wave amplitude (μV mean ± SD)
Normal 13.78 ± 1.90** 19.23 ± 1.64** 2.60 ± 0.24**
EAE 25.58 ± 6.36 37.13 ± 1.10 0.58 ± 0.08
CNTF 18.95 ± 4.57* 26.13 ± 1.15* 0.90 ± 0.26*
Reg-2 15.97 ± 0.12* 21.53 ± 0.21* 1.30 ± 0.40**

*P < 0.05 vs. vehicle-treated EAE rats. **P < 0.01 vs. vehicle-treated EAE rats. N, negative deflection; P, positive deflection.


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