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Article: Reg-2, A Downstream Signaling Protein in the Ciliary Neurotrophic Factor Survival Pathway, Alleviates Experimental Autoimmune Encephalomyelitis.

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Jiang H; Tian KW; Zhang F; Wang B; Han S
Front Neuroanat, 2016


CNTF treatment and Reg-2 treatment reduce c-MEP latency and increase c-MEP amplitude at 2 weeks post-immunization.

2 weeks
Groups Latency (ms) Wave amplitude (μV mean ± SD)
Normal 5.15 ± 0.17* 3.02 ± 0.73**
EAE 7.73 ± 2.31 0.21 ± 0.01
CNTF 5.8 ± 0.25* 2.13 ± 0.23**
Reg-2 5.57 ± 0.26* 2.03 ± 0.38**

*P < 0.05 vs. vehicle-treated EAE rats. **P < 0.01 vs. vehicle-treated EAE rats.


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