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Article: Reg-2, A Downstream Signaling Protein in the Ciliary Neurotrophic Factor Survival Pathway, Alleviates Experimental Autoimmune Encephalomyelitis.

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Jiang H; Tian KW; Zhang F; Wang B; Han S
Front Neuroanat, 2016


CNTF treatment and Reg-2 treatment reduce c-MEP latency and increase c-MEP amplitude at 8 weeks post-immunization.

8 weeks
Groups Latency (ms) Wave amplitude (μV mean ± SD)
Normal 3.56 ± 0.77** 3.78 ± 1.06**
EAE 6.8 ± 0.15 0.22 ± 0.08
CNTF 5.3 ± 0.08* 1.2 ± 0.23**
Reg-2 5.2 ± 0.14* 1.63 ± 0.15**

*P < 0.05 vs. vehicle-treated EAE rats. **P < 0.01 vs. vehicle-treated EAE rats.


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