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Article: Intrinsic membrane properties determine hippocampal differential firing pattern in vivo in anesthetized rats.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Kowalski J; Gan J; Jonas P; Pernía-Andrade AJ
Hippocampus, 2016


Table 1. Intrinsic and Synaptic Properties of Hippocampal Principal Neurons In Vivo
CA3CA1GCPCA3-CA1PCA1-GCPCA3-GC
Passive properties, sag ratio
Vrest (mV)-56.9 ± 0.7 (41)-60.5 ± 1.1 (13)-74.7 ± 0.9 (18)0.010*<0.001*<0.001*
Input resistance (MΩ)186 ± 8 (41)77 ± 7 (13)122 ± 13 (18)<0.001*0.002*<0.001*
Membrane time constant (ms)50 ± 4 (9)12 ± 1 (6)16 ± 1 (5)<0.001*0.017*<0.001*
Sag ratio (%)1.7 ± 0.2 (11)1.6 ± 0.2 (10)1.0 ± 0.2 (6)0.5570.0420.015*
Active properties - evoked firing, first AP
AP voltage threshold (mV)-42.3 ± 0.4 (41)-48.4 ± 0.5 (13)-40.8 ± 0.6 (18)<0.001*<0.001*0.034*
AP current threshold (pA)18 ± 3 (36)20 ± 7 (13)135 ± 11 (18)0.643<0.001*<0.001*
AP amplitude (mV)62 ± 1 (41)76 ± 3 (13)67 ± 2 (18)<0.001*0.020*0.170*
AP half-duration (ms)0.72 ± 0.02 (41)0.74 ± 0.03 (13)0.55 ± 0.02 (18)0.659<0.001*<0.001*
AP max. slope of rise (V s-1)287 ± 11 (41)500 ± 44 (13)378 ± 29 (18)<0.001*0.047*0.007*
fast AHP (mV)3.1 ± 0.4 (6)a-a7.6 ± 0.6 (18)--0.002*
ADP (mV)1.2 ± 0.4 (3)a-a5.1 ± 0.7 (7)a--0.033*
Active properties - evoked firing, repetitive spiking properties
Gain (Hz pA-1)10 ± 1 (36)12 ± 1 (13)53 ± 4 (18)0.272<0.001*<0.001*
Spike frequency (Hz)b26.2 ± 1.8 (34)32 ± 2 (9)24.5 ± 6 (17)0.1230.0680.223
CV of ISIb1.40 (34)1.47 (9)1.15 (13)0.7140.1100.132
Combined AP & burst frequency (Hz)b7.9 ± 0.5 (34)10.6 ± 0.9 (9)19.2 ± 5 (17)0.022*0.4810.092
Spikes per burstb4.18 ± 0.34 (34)3 ± 0.24 (9)2.64 ± 0.39 (11)c0.1820.1020.007*
ISI within burst (ms)b7.8 ± 0.57 (34)5.1 ± 0.34 (9)4.06 ± 0.13 (11)c0.016*0.020*<0.001*
Spontaneous action potentials and bursts
Total AP frequency (Hz)3.4 ± 0.9 (9)6.4 ± 1.1 (5)0 (6)0.0830.008*<0.001*
Single AP frequency (Hz)0.04 ± 0.02 (9)0.05 ± 0.01 (5)0 (6)0.170.002*0.024*
Burst frequency (Hz)0.7 ± 0.2 (9)1.4 ± 0.3 (5)0 (6)0.1470.002*<0.001*
Proportion of bursts (%)86.5 ± 2.4 (34)96.3 ± 0.8 (5)-0.275--
ISI within burst (ms)4.9 ± 0.2 (34)4.7 ± 0.3 (5)-0.97--
Spikes per burst6.4 ± 0.4 (34)4.2 ± 0.4 (5)-0.024*--
Interburst interval (s)0.76 ± 0.17 (9)0.27 ± 0.05 (5)-0.042*--
Interburst interval distribution τ1 (ms)711 ± 10 (9)237 ± 8 (5)----
Interburst interval distribution A1 (%)75 ± 1 (9)65 ± 2 (5)----
Interburst interval distribution τ2 (s)3.1 ± 0.1 (9)1.28 ± 0.05 (5)----
Interburst interval distribution A2 (%)25 ± 1 (9)34 ± 2 (5)----
Single AP voltage threshold (mV)-43.9 ± 0.6 (7)-47.2 ± 2.3 (3)----
Single AP peak amplitude (mV)61 ± 3 (7)53 ± 1 (3)----
Single AP half-duration (ms)0.74 ± 0.05 (7)0.86 ± 0.02 (3)----
Single AP max. slope of rise (V s-1)282 ± 27 (7)235 ± 15 (3)----
ADP (mV)0.29 ± 0.12 (7)0.22 ± 0.12 (3)----
APburst voltage threshold (mV)-44.5 ± 0.6 (9)-49.7 ± 1.3 (5)-0.004*--
APburst peak amplitude (mV)61 ± 3 (9)61 ± 3 (5)->0.9--
APburst half-duration (ms)0.75 ± 0.04 (9)0.82 ± 0.04 (5)-0.35--
APburst max. slope of rise (V s-1)267 ± 28 (9)322 ± 47 (5)-0.438--
Spontaneous EPSPs and IPSPs
EPSP frequency (Hz)16.8 ± 2.3 (6)14.2 ± 1.3 (5)24.1 ± 5.3 (5)0.6620.2220.247
EPSP peak amplitude (mV)1.2 ± 0.1 (6)1.4 ± 0.1 (5)1.3 ± 0.2 (5)0.1780.5480.662
EPSP 20 - 80% rise time (ms)3.1 ± 0.1 (6)3.5 ± 0.1 (5)2.1 ± 0.1 (5)0.017*0.008*0.004*
EPSP τdecay (ms)10.7 ± 1.6 (6)8.4 ± 0.7 (5)6.2 ± 0.6 (5)0.2470.0560.009*
Time-averaged EPSP amplitude (mV)1.3 ± 0.1 (6)1.5 ± 0.1 (5)1.9 ± 0.5 (5)0.6620.6910.662
Time-averaged IPSP amplitude (mV)0.48 ± 0.10 (6)0.41 ± 0.05 (5)0.07 ± 0.01 (5)>0.90.008*0.004*

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell input resistance (MΩ) 186.0 ± 8.0 (41) 186.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 77.0 ± 7.0 (13) 77.0 (MΩ) Data Table
Dentate gyrus granule cell input resistance (MΩ) 122.0 ± 13.0 (18) 122.0 (MΩ) Data Table
Hippocampus CA3 pyramidal cell membrane time constant (ms) 50.0 ± 4.0 (9) 50.0 (ms) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 12.0 ± 1.0 (6) 12.0 (ms) Data Table
Dentate gyrus granule cell membrane time constant (ms) 16.0 ± 1.0 (5) 16.0 (ms) Data Table
Hippocampus CA3 pyramidal cell sag ratio 1.7 ± 0.2 (11) 0.017 (ratio) Data Table
Hippocampus CA1 pyramidal cell sag ratio 1.6 ± 0.2 (10) 0.016 (ratio) Data Table
Dentate gyrus granule cell sag ratio 1.0 ± 0.2 (6) 0.01 (ratio) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -56.9 ± 0.7 (41) -56.9 (mV) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -42.3 ± 0.4 (41) -42.3 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -48.4 ± 0.5 (13) -48.4 (mV) Data Table
Dentate gyrus granule cell spike threshold (mV) -40.8 ± 0.6 (18) -40.8 (mV) Data Table
Hippocampus CA3 pyramidal cell rheobase (pA) 18.0 ± 3.0 (36) 18.0 (pA) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -60.5 ± 1.1 (13) -60.5 (mV) Data Table
Hippocampus CA1 pyramidal cell rheobase (pA) 20.0 ± 7.0 (13) 20.0 (pA) Data Table
Dentate gyrus granule cell rheobase (pA) 135.0 ± 11.0 (18) 135.0 (pA) Data Table
Hippocampus CA3 pyramidal cell spike amplitude (mV) 62.0 ± 1.0 (41) 62.0 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 76.0 ± 3.0 (13) 76.0 (mV) Data Table
Dentate gyrus granule cell spike amplitude (mV) 67.0 ± 2.0 (18) 67.0 (mV) Data Table
Dentate gyrus granule cell resting membrane potential (mV) -74.7 ± 0.9 (18) -74.7 (mV) Data Table
Hippocampus CA3 pyramidal cell spike half-width (ms) 0.72 ± 0.02 (41) 0.72 (ms) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 0.74 ± 0.03 (13) 0.74 (ms) Data Table
Dentate gyrus granule cell spike half-width (ms) 0.55 ± 0.02 (18) 0.55 (ms) Data Table
Hippocampus CA3 pyramidal cell spike max rise slope 287.0 ± 11.0 (41) 287.0 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope 500.0 ± 44.0 (13) 500.0 (mV/ms) Data Table
Dentate gyrus granule cell spike max rise slope 378.0 ± 29.0 (18) 378.0 (mV/ms) Data Table
Hippocampus CA3 pyramidal cell fast AHP amplitude (mV) 3.1 ± 0.4 (6) 3.1 (mV) Data Table
Dentate gyrus granule cell fast AHP amplitude (mV) 7.6 ± 0.6 (18) 7.6 (mV) Data Table
Hippocampus CA3 pyramidal cell ADP amplitude (mV) 1.2 ± 0.4 (3) 1.2 (mV) Data Table
Dentate gyrus granule cell ADP amplitude (mV) 5.1 ± 0.7 (7) 5.1 (mV) Data Table
Hippocampus CA3 pyramidal cell FI slope 10.0 ± 1.0 (36) 10.0 (Hz/nA) Data Table
Hippocampus CA1 pyramidal cell FI slope 12.0 ± 1.0 (13) 12.0 (Hz/nA) Data Table
Dentate gyrus granule cell FI slope 53.0 ± 4.0 (18) 53.0 (Hz/nA) Data Table
Hippocampus CA3 pyramidal cell firing frequency (Hz) 26.2 ± 1.8 (34) 26.2 (Hz) Data Table
Hippocampus CA1 pyramidal cell firing frequency (Hz) 32.0 ± 2.0 (9) 32.0 (Hz) Data Table
Dentate gyrus granule cell firing frequency (Hz) 24.5 ± 6.0 (17) 24.5 (Hz) Data Table