Article: Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome.
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Taneja P; Ogier M; Brooks-Harris G; Schmid DA; Katz DM; Nelson SB
J. Neurosci., 2009
Table 1: Locus Coeruleus Neuron Electrophysiology gathered from Materials and Methods
|
Spontaneous Firing Frequency (Hz) |
Spike Threshold mV |
AHP (mV) |
Input Resistance without Blockade (Mohm) |
Input Resistance with Blockade (Mohm) |
RMP Without Blockade (mV) |
RMP With Blockade (mV) |
Membrane Capacitance (pF) |
Soma Area (um^2) |
Adaptation Coef. (2nd/Last ISI) |
FI Slope (Hz/pA) |
| LC WT Neuron (n=36) |
0.8 +/- 0.1 |
-29.4 +/- 0.6 |
-24.4 +/- 0.7 |
430 +/- 30 |
320 +/- 20 |
-43.1 +/- 0.7 |
-49 +/- 1 |
130 +/- 4 |
332 +/- 6 |
0.6 |
0.06 |
| HET+ (n=29) |
|
|
|
|
|
|
|
92.9 |
353 +/- 9 |
0.4 |
0.06 |
| HET- (n=21) |
|
|
|
|
|
|
|
126 |
277 +/- 6 |
1.3 |
0.09 |
| Null (n=34) |
|
|
|
|
|
|
|
89.1 |
260 +/- 9 |
1.0 |
0.09 |
| Blockade refers to the Synaptic blockade using AMPA, NMDA and GABAa receptor blockers. Het refers to Heterozygous genotypes. Null refers to knockout.: |
Inferred neuron-electrophysiology data values
