Article: Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch.
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Dehorter N; Ciceri G; Bartolini G; Lim L; del Pino I; Marín O
Science, 2015
Figure S6: Fig. S6. Postnatal deletion of Er81 from PV+ interneurons impacts their intrinsic properties.
|
PV-Cre;Er81+/+ |
PV-Cre;Er81F/F |
P values |
| Vrest (mV) |
-72.4 +/- .09 |
-69.4 +/- 1.3 |
0.07 |
| Cm (pF) |
27.7 +/- 1.2 |
27.8 +/- 1.7 |
0.97 |
| Rm (MOhm) |
134.1 +/- 7.9 |
131.4 +/- 7.4 |
0.77 |
| Rheobase (pA) |
202.1 +/- 16.2 |
139.4 +/- 18.8 |
(*) 0.02 |
| V threshold (mV) |
-37.5 +/- 1.2 |
-42.9 +/- 2.0 |
(*) 0.02 |
| AP amplitude (mV) |
48.6 +/- 2.2 |
50.2 +/- 2.2 |
0.62 |
| AP rise duration (ms) |
0.28 +/- .02 |
0.28 +/- .02 |
0.94 |
| AP tot duration (ms) |
0.82 +/- .04 |
0.87 +/- .03 |
0.32 |
| AHP amplitude (mV) |
17.08 +/- .79 |
17.31 +/- .94 |
0.85 |
| AHP duration (ms) |
0.16 +/- .01 |
0.15 +/- .01 |
0.54 |
| Latency to the 1st spike (ms) |
220.03 +/- 21.38 |
92.38 +/- 13.33 |
(***) .00004 |
| Exponential fit (mV) |
4.3 +/- .4 |
1.3 +/- .7 |
(***) 0.0002 |
| MFF (Hz) |
147.7 +/- 10.0 |
182.9 +/- 15.0 |
0.04 |
| Number of cells |
29 |
20 |
|
| (D) Intrinsic electrophysiological properties of PV+ interneurons in cortical layer II-III of control and PV-Cre;Er81 conditional mutants. Vrest: resting membrane potential; Cm: membrane capacitance; Rm: membrane resistance; Vthreshold: Threshold potential for spike; AP: Action potential; AHP: After hyperpolarization; MFF: Maximum firing frequency. Graphs represent mean +\- s.e.m.: |
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |
