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Article: Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.

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Tai C; Abe Y; Westenbroek RE; Scheuer T; Catterall WA
Proc. Natl. Acad. Sci. U.S.A., 2014


Table 1: Electrophysiological parameters of pyramidal neurons and interneurons in neocortex
PV interneruons WT (n=19) PV interneurons HET (n=18) SST interneurons WT (n=21) SST interneurons HET (n=23) Pyramidal neurons WT (n=35) Pyramidal neurons HET (n=35)
Vrest, mV -65.5 +/- 0.7 -65.1 +/- 0.7 -73.2 +/- 1.0 -73.5 +/- 0.4 -58.2 +/- 0.6 -59.1 +/- 0.6
Rin, Mohm 174.1 +/- 14.8 172.7 +/- 18.4 326.9 +/- 29.6 312.9 +/- 15.0 260.0 +/- 20.4 251.0 +/- 13.2
Cm, pF 29.2 +/- 1.0 30.8 +/- 1.7 24.8 +/- 1.3 25.4 +/- 1.6 39.2 +/- 1.8 40.8 +/- 1.9
Rheobase, pA 178.4 +/- 12.0 241.1 +/- 22.0** 51.9 +/- 6.6 82.6 +/- 4.7*** 98.6 +/- 5.5 94.3 +/- 4.9
Threshold, mV -33.9 +/- 1.0* -30.9 +/- 1.0 -38.3 +/- 1.0 -35.5 +/- 0.7* -32.1 +/- 1.0 -31.7 +/- 0.9
Amplitude, mV 56.1 +/- 1.4 52.4 +/- 1.7* 86.5 +/- 1.7 87.1 +/- 1.1 81.8 +/- 0.9 82.6 +/- 1.1
AP half width, ms 0.72 +/- 0.03 0.78 +/- 0.05 1.49 +/- 0.08 1.43 +/- 0.06 2.1 +/- 0.09 1.9 +/- 0.09
Frequency, Hz 57.8 +/- 4.5 31.5 +/- 6.5*** 40.9 +/- 3.8 29.7 +/- 2.5*** 14.2 +/- 1.5 15.6 +/- 1.1
AP amplitude adaptation ratio 0.90 +/- 0.03 0.91 +/- 0.02 1.01 +/- 0.03 1.02 +/- 0.03 0.92 +/- 0.04 0.94 +/- 0.04
AP frequency adaptation ratio 0.75 +/- 0.02 0.74 +/- 0.02 0.36 +/- 0.03 0.38 +/- 0.02 0.85 +/- 0.03 0.86 +/- 0.04
For an explanation of the parameters, see Materials and Methods. Values shown are expressed as mean ± SEM. Significant differences between WT and HET are expressed as *P

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell input resistance (Mohm) 326.9 ± 29.6 (21) 326.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell input resistance (Mohm) 260.0 ± 20.4 (35) 260.0 (MΩ) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell cell capacitance (pF) 29.2 ± 1.0 (19) 29.2 (pF) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell cell capacitance (pF) 24.8 ± 1.3 (21) 24.8 (pF) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell resting membrane potential (mV) -65.5 ± 0.7 (19) -65.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell cell capacitance (pF) 39.2 ± 1.8 (35) 39.2 (pF) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell rheobase (pA) 178.4 ± 12.0 (19) 178.4 (pA) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell rheobase (pA) 51.9 ± 6.6 (21) 51.9 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell rheobase (pA) 98.6 ± 5.5 (35) 98.6 (pA) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell spike threshold (mV) -33.9 ± 1.0 (19) -33.9 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell spike threshold (mV) -38.3 ± 1.0 (21) -38.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell spike threshold (mV) -32.1 ± 1.0 (35) -32.1 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell spike amplitude (mV) 56.1 ± 1.4 (19) 56.1 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell spike amplitude (mV) 86.5 ± 1.7 (21) 86.5 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell resting membrane potential (mV) -73.2 ± 1.0 (21) -73.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell spike amplitude (mV) 81.8 ± 0.9 (35) 81.8 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell spike half-width (ms) 0.72 ± 0.03 (19) 0.72 (ms) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell spike half-width (ms) 1.49 ± 0.08 (21) 1.49 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell spike half-width (ms) 2.1 ± 0.09 (35) 2.1 (ms) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell firing frequency (Hz) 57.8 ± 4.5 (19) 57.8 (Hz) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell firing frequency (Hz) 40.9 ± 3.8 (21) 40.9 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell firing frequency (Hz) 14.2 ± 1.5 (35) 14.2 (Hz) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell other 0.9 ± 0.03 (19) 0.9 (None) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell resting membrane potential (mV) -58.2 ± 0.6 (35) -58.2 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell other 1.01 ± 0.03 (21) 1.01 (None) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell other 0.92 ± 0.04 (35) 0.92 (None) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell adaptation ratio 0.75 ± 0.02 (19) 0.75 (ratio) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 somatostatin expressing Martinotti cell adaptation ratio 0.36 ± 0.03 (21) 0.36 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal cell adaptation ratio 0.85 ± 0.03 (35) 0.85 (ratio) Data Table
Neocortex basket cell Somatosensory cortex layer 5 parvalbumin expressing basket cell input resistance (Mohm) 174.1 ± 14.8 (19) 174.1 (MΩ) Data Table