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Article: Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice.

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Sceniak MP; Lang M; Enomoto AC; Howell CJ; Hermes DJ; Katz DM
Cereb. Cortex, 2016


Table 1- From text around Figure 4 and Figure 4 le: Intrinsic action potential properties between Wt and Mecp2 null neurons.
Rin (M Ohm) Cm (pF) Vm (mV) AP duration (ms) AP amplitude (mV)
WT (n=5) 98 +/- 7.8 142 +/- 6.5 -65 +/- 0.8 2.70 81.5
Mecp2 null (n=5) 105 +/- 10 127 +/- 4.2 -63 +/- 1.2 2.73 83.3
(A) Representative voltage traces from Wt and Mecp2 null excitatory pyramidal layer 5 mPFC neurons in response to current injections. Individual action potential properties were analyzed (see dashed box and inset) to determine the amplitude and half-height spike duration (D) between Wt and Mecp2 null neurons. (B) Across the population of neurons examined (n = 5 neurons with 7 repeats per neuron for both Wt and Mecp2 null animals), spike duration was not significantly different between Wt and Mecp2 null neurons (mean duration = 2.70 and 2.73 ms, respectively). (C) There was a small but significant increase in the mean spike amplitude between Wt and Mecp2 null neurons (81.5 and 83.3 mV, respectively; P = 3e-17, Mann Whitney U-test).:

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Medial Prefrontal Cortex layer 5 pyramidal excitatory neurons input resistance 98.0 ± 7.8 (5) 98.0 (MΩ) Data Table
Other Medial Prefrontal Cortex layer 5 pyramidal excitatory neurons cell capacitance (pF) 142.0 ± 6.5 (5) 142.0 (pF) Data Table
Other Medial Prefrontal Cortex layer 5 pyramidal excitatory neurons resting membrane potential (mV) -65.0 ± 0.8 (5) -65.0 (mV) Data Table
Other Medial Prefrontal Cortex layer 5 pyramidal excitatory neurons spike half-width (ms) 2.7 (5) 2.7 (ms) Data Table
Other Medial Prefrontal Cortex layer 5 pyramidal excitatory neurons spike amplitude (mV) 81.5 (5) 81.5 (mV) Data Table