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Article: The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I(h) and GABAergic synaptic integration.

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Tateno T; Robinson HP
J. Neurophysiol., 2011


Table 1.

Summary of properties of immunochemically identified SNc and VTA DA neurons and SNr non-DA neurons

Cells n Input Resistance, MΩ Spontaneous FF, Hz Rebound Delay. ms Ih Sag, mV AP Threshold, mV AP Width. ms AP Amplitude, mV Pseudo RP, mV
SNc DA 36 476 ± 28 2.27 ± 1.28 292 ± 25 41.0 ± 2.4 32.5 ± 1.7 1.93 ± 0.66 55.6 ± 5.1 54.6 ± 1.7
VTA DA 42 518 ± 27 2.12 ± 1.12 818 ± 65* 45.6 ± 2.3 34.1 ± 2.1 2.01 ± 0.71 56.3 ± 4.9 55.0 ± 2.1
SNr non-DA 68 549 ± 17* 15.2 ± 0.7* 84.4 ± 3.9* 15.1 ± 1.0* 50.7 ± 2.9* 1.20 ± 0.22 * 78.6 ± 3.7* 59.6 ± 4.1

  • Values are means ± SE; n = no. of cells.

  • ↵* P < 0.05, significant differences compared with values obtained from SNc DA neurons (ANOVA). SNc, substantia nigra pars compacta; SNr, substantia nigra pars reticulata; DA, dopaminergic; VTA, ventral tegmental area; FF, firing frequency; AP, action potential; RP, resting potential.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Substantia nigra pars compacta dopaminergic cell resting membrane potential (mV) 54.6 ± 1.7 (36) -54.6 (mV) Data Table
Ventral tegmental area dopamine neuron input resistance (MΩ) 518.0 ± 27.0 (42) 518.0 (MΩ) Data Table
Ventral tegmental area dopamine neuron spontaneous firing rate (Hz) 2.12 ± 1.12 (42) 2.12 (Hz) Data Table
Ventral tegmental area dopamine neuron sag amplitude (mV) 45.6 ± 2.3 (42) 45.6 (mV) Data Table
Ventral tegmental area dopamine neuron spike threshold (mV) 34.1 ± 2.1 (42) -34.1 (mV) Data Table
Ventral tegmental area dopamine neuron spike half-width (ms) 2.01 ± 0.71 (42) 2.01 (ms) Data Table
Ventral tegmental area dopamine neuron spike amplitude (mV) 56.3 ± 4.9 (42) 56.3 (mV) Data Table
Ventral tegmental area dopamine neuron resting membrane potential (mV) 55.0 ± 2.1 (42) -55.0 (mV) Data Table
Substantia nigra pars reticulata interneuron GABA input resistance (MΩ) 549.0 ± 17.0 (68) 549.0 (MΩ) Data Table
Substantia nigra pars reticulata interneuron GABA spontaneous firing rate (Hz) 15.2 ± 0.7 (68) 15.2 (Hz) Data Table
Substantia nigra pars reticulata interneuron GABA sag amplitude (mV) 15.1 ± 1.0 (68) 15.1 (mV) Data Table
Substantia nigra pars reticulata interneuron GABA spike threshold (mV) 50.7 ± 2.9 (68) -50.7 (mV) Data Table
Substantia nigra pars reticulata interneuron GABA spike half-width (ms) 1.2 ± 0.22 (68) 1.2 (ms) Data Table
Substantia nigra pars reticulata interneuron GABA spike amplitude (mV) 78.6 ± 3.7 (68) 78.6 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell input resistance (MΩ) 476.0 ± 28.0 (36) 476.0 (MΩ) Data Table
Substantia nigra pars reticulata interneuron GABA resting membrane potential (mV) 59.6 ± 4.1 (68) -59.6 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell spontaneous firing rate (Hz) 2.27 ± 1.28 (36) 2.27 (Hz) Data Table
Substantia nigra pars compacta dopaminergic cell sag amplitude (mV) 41.0 ± 2.4 (36) 41.0 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell spike threshold (mV) 32.5 ± 1.7 (36) -32.5 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell spike half-width (ms) 1.93 ± 0.66 (36) 1.93 (ms) Data Table
Substantia nigra pars compacta dopaminergic cell spike amplitude (mV) 55.6 ± 5.1 (36) 55.6 (mV) Data Table