TABLE 2.Proportions of spinally projecting RVM neurons responsive to 1 or 3 µM DAMGO
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Type 1 | Type 2 | Type 3 | |
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Serotonergic | 6/11 (55) | 2/7 (29) | 1/12* (8) |
Nonserotonergic | 3/5 (60) | 3/13 (23) | 5/17 (29) |
A neuron was considered responsive if 1 or 3 µM DAMGO produced an outward current ≥10 pA that was reversed by 1 µM naloxone;
inward currents were never observed after application of [D-Ala2, NMePhe4-Gly5-ol]enkephalin (DAMGO).
* P < 0.05,
**P < 0.01 compared to type 1 neurons within that immunohistochemical classification. Percentage in parentheses.