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Article: Two populations of layer v pyramidal cells of the mouse neocortex: development and sensitivity to anesthetics.

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Christophe E; Doerflinger N; Lavery DJ; Molnár Z; Charpak S; Audinat E
J. Neurophysiol., 2005



TABLE 2.Passive and active electrophysiological characteristics of the two populations of layer V pyramidal cells (CC- and SC-projecting neurons) at two developmental stages (P5–7 and P21–30)
P5–7 CC cells P5–7 SC cells P21–30 CC cells P21–30 SC cells
Resting potential, mV –68.3 ± 1.3 (n = 19) –68.5 ± 1.7 (n = 18) –76.6 ± 1.5 (n = 25) –75.3 ± 1.5 (n = 18)
Input resistance, MΩ 424.5 ± 41.6 (n = 19) 309.3 ± 21.7* (n = 18) 156.8 ± 7.7 (n = 25) 115.5 ± 9.2* (n = 18)
Amplitude of 1h rectification, mV 4.6 ± 0.6 (n = 19) 10.0 ± 1.0** (n = 18) 2.5 ± 0.3 (n = 25) 5.1 ± 0.4** (n = 18)
Action potential threshold, mV –40.0 ± 1.0 (n = 19) –42.6 ± 0.6* (n = 18) –45.9 ± 0.8 (n = 25) –52.5 ± 0.6** (n = 18)
Action potential amplitude, mV 67.6 ± 1.4 (n = 19) 70.7 ± 1.8 (n = 18) 83.7 ± 1.4 (n = 25) 88.9 ± 1.2* (n = 18)
Duration at midheight, ms 1.8 ± 0.1 (n = 19) 2.0 ± 0.1 (n = 18) 0.80 ± 0.03 (n = 25) 0.80 ± 0.03 (n = 18)
Duration at threshold, ms 3.9 ± 0.2 (n = 19) 4.3 ± 0.3 (n = 18) 1.80 ± 0.09 (n = 25) 1.80 ± 0.08 (n = 18)
Frequency adaptation, % 40.2 ± 3.9 (n = 8) 32.8 ± 4.1 (n = 8) 77.3 ± 2.2 (n = 7) 76.7 ± 1.6 (n = 8)
Statistics correspond to the comparison of the two populations at a given developmental stage.

* P < 0.05;

** P < 0.001.

See RESULTS for more statistics and METHODS for determination of the parameters.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell resting membrane potential (mV) -68.3 ± 1.3 (19) -68.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus resting membrane potential (mV) -68.5 ± 1.7 (18) -68.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell resting membrane potential (mV) -76.6 ± 1.5 (25) -76.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus resting membrane potential (mV) -75.3 ± 1.5 (18) -75.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell input resistance (MΩ) 424.5 ± 41.6 (19) 424.5 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus input resistance (MΩ) 309.3 ± 21.7 (18) 309.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell input resistance (MΩ) 156.8 ± 7.7 (25) 156.8 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus input resistance (MΩ) 115.5 ± 9.2 (18) 115.5 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike threshold (mV) -40.0 ± 1.0 (19) -40.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike threshold (mV) -42.6 ± 0.6 (18) -42.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike threshold (mV) -45.9 ± 0.8 (25) -45.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike threshold (mV) -52.5 ± 0.6 (18) -52.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike amplitude (mV) 67.6 ± 1.4 (19) 67.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike amplitude (mV) 70.7 ± 1.8 (18) 70.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike amplitude (mV) 83.7 ± 1.4 (25) 83.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike amplitude (mV) 88.9 ± 1.2 (18) 88.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike half-width (ms) 1.8 ± 0.1 (19) 1.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike half-width (ms) 2.0 ± 0.1 (18) 2.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike half-width (ms) 0.8 ± 0.03 (25) 0.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike half-width (ms) 0.8 ± 0.03 (18) 0.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike width (ms) 3.9 ± 0.2 (19) 3.9 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike width (ms) 4.3 ± 0.3 (18) 4.3 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell spike width (ms) 1.8 ± 0.09 (25) 1.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus spike width (ms) 1.8 ± 0.08 (18) 1.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell adaptation percent (1 – first/last ISI) 40.2 ± 3.9 (8) 40.2 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus adaptation percent (1 – first/last ISI) 32.8 ± 4.1 (8) 32.8 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 corticocortical pyramidal cell adaptation percent (1 – first/last ISI) 77.3 ± 2.2 (7) 77.3 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 visual cortex layer 5 thick tufted pyramidal cell projecting to superior colliculus adaptation percent (1 – first/last ISI) 76.7 ± 1.6 (8) 76.7 (ratio) Data Table