TABLE 1.Electrophysiological properties of large-diameter DRG neurons
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Treatment | Sham | Saline Axot | Saline Unaxot | Clonidine Axot | Clonidine Unaxot |
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Cell size, µm | 54.6 ± 0.85 | 53.2 ± 1.12 | 55.18 ± 1.14 | 53.4 ± 1.23 | 55.6 ± 1.11 |
n | 36 | 27 | 18 | 27 | 22 |
Vm, mV | –64.2 ± 0.55 | –60.7 ± 1.24* | –61.8 ± 1.02* | –64.3 ± 0.80# | –63.8 ± 1.43# |
n | 36 | 27 | 18 | 27 | 22 |
Voltage threshold, mV | –34.7 ± 1.41 | –40.9 ± 1.39* | –40.9 ± 1.72* | –36.7 ± 1.34# | –37.9 ± 1.77 |
n | 36 | 27 | 18 | 27 | 22 |
AP height, mV | 63.3 ± 1.49 | 65.2 ± 1.42 | 66.1 ± 1.53 | 66.5 ± 1.49 | 62.7 ± 2.27 |
n | 36 | 27 | 18 | 27 | 22 |
Rheobase, nA | 1.6 ± 0.12 | 0.8 ± 0.08* | 0.9 ± 0.09* | 1.2 ± 0.12*# | 1.2 ± 0.14* |
n | 36 | 27 | 18 | 27 | 22 |
AP-D, ms | 0.9 ± 0.05 | 2.2 ± 0.11* | 1.5 ± 0.09*§ | 2.0 ± 0.15* | 1.8 ± 0.16* |
n | 36 | 27 | 18 | 27 | 22 |
AHP, mV | 11.6 ± 0.58 | 8.2 ± 0.62* | 9.3 ± 0.86 | 7.1 ± 0.73* | 11.1 ± 1.02 |
n | 35 | 22 | 18 | 27 | 20 |
AHP-D, ms | 2.8 ± 0.19 | 3.5 ± 0.26 | 3.6 ± 0.43 | 3.4 ± 0.39 | 3.6 ± 0.68 |
n | 35 | 22 | 18 | 27 | 20 |
Rin, MΩ | 15.2 ± 1.15 | 21.5 ± 2.08* | 26.1 ± 4.43* | 24.2 ± 2.08* | 18.3 ± 1.41 |
n | 35 | 27 | 17 | 26 | 22 |
aV/aT r., mV/ms | 326.7 ± 14.59 | 205.4 ± 13.07* | 220.8 ± 15.65* | 239.6 ± 16.14* | 225.0 ± 20.28* |
n | 36 | 27 | 18 | 27 | 22 |
aV/aT f., mV/ms | 154.2 ± 14.06 | –69.6 ± 4.53* | 100.8 ± 8.55*§ | –75.3 ± 5.59* | –90.0 ± 8.77* |
n | 36 | 27 | 18 | 27 | 22 |
Values, expressed as means ± SE, were obtained from both L4 and L5 dorsal root ganglion large neurons; n = recorded number of neurons. Cell size is the diameter.
* P < 0.05, PSNL group versus Sham group;
§ P < 0.05, unaxotomized (unaxot) group versus corresponding axotomized (axot) group;
# P < 0.05, clonidine-treated group versus corresponding saline control.