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Article: Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury.

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Liu B; Eisenach JC
J. Neurophysiol., 2005



TABLE 1.Electrophysiological properties of large-diameter DRG neurons


Treatment Sham Saline Axot Saline Unaxot Clonidine Axot Clonidine Unaxot

Cell size, µm 54.6 ± 0.85 53.2 ± 1.12 55.18 ± 1.14 53.4 ± 1.23 55.6 ± 1.11
    n 36 27 18 27 22
Vm, mV –64.2 ± 0.55 –60.7 ± 1.24* –61.8 ± 1.02* –64.3 ± 0.80# –63.8 ± 1.43#
    n 36 27 18 27 22
Voltage threshold, mV –34.7 ± 1.41 –40.9 ± 1.39* –40.9 ± 1.72* –36.7 ± 1.34# –37.9 ± 1.77
    n 36 27 18 27 22
AP height, mV 63.3 ± 1.49 65.2 ± 1.42 66.1 ± 1.53 66.5 ± 1.49 62.7 ± 2.27
    n 36 27 18 27 22
Rheobase, nA 1.6 ± 0.12 0.8 ± 0.08* 0.9 ± 0.09* 1.2 ± 0.12*# 1.2 ± 0.14*
    n 36 27 18 27 22
AP-D, ms 0.9 ± 0.05 2.2 ± 0.11* 1.5 ± 0.09*§ 2.0 ± 0.15* 1.8 ± 0.16*
    n 36 27 18 27 22
AHP, mV 11.6 ± 0.58 8.2 ± 0.62* 9.3 ± 0.86 7.1 ± 0.73* 11.1 ± 1.02
    n 35 22 18 27 20
AHP-D, ms 2.8 ± 0.19 3.5 ± 0.26 3.6 ± 0.43 3.4 ± 0.39 3.6 ± 0.68
    n 35 22 18 27 20
Rin, MΩ 15.2 ± 1.15 21.5 ± 2.08* 26.1 ± 4.43* 24.2 ± 2.08* 18.3 ± 1.41
    n 35 27 17 26 22
aV/aT r., mV/ms 326.7 ± 14.59 205.4 ± 13.07* 220.8 ± 15.65* 239.6 ± 16.14* 225.0 ± 20.28*
    n 36 27 18 27 22
aV/aT f., mV/ms 154.2 ± 14.06 –69.6 ± 4.53* 100.8 ± 8.55*§ –75.3 ± 5.59* –90.0 ± 8.77*
    n 36 27 18 27 22

Values, expressed as means ± SE, were obtained from both L4 and L5 dorsal root ganglion large neurons; n = recorded number of neurons. Cell size is the diameter.

* P < 0.05, PSNL group versus Sham group;

§ P < 0.05, unaxotomized (unaxot) group versus corresponding axotomized (axot) group;

# P < 0.05, clonidine-treated group versus corresponding saline control.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell input resistance (MΩ) 15.2 ± 1.15 (36) 15.2 (MΩ) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell cell diameter 54.6 ± 0.85 (36) 54.6 (um) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell spike max rise slope (mV/ms) 326.7 ± 14.59 (36) 326.7 (mV/ms) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell spike max decay slope (mV/ms) 154.2 ± 14.06 (36) 154.2 (mV/ms) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell resting membrane potential (mV) -64.2 ± 0.55 (36) -64.2 (mV) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell spike threshold (mV) -34.7 ± 1.41 (36) -34.7 (mV) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell spike amplitude (mV) 63.3 ± 1.49 (36) 63.3 (mV) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell rheobase (nA) 1.6 ± 0.12 (36) 1600.0 (pA) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell spike width (ms) 0.9 ± 0.05 (36) 0.9 (ms) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell AHP amplitude (mV) 11.6 ± 0.58 (36) 11.6 (mV) Data Table
Dorsal root ganglion cell lumbar 4 and lumbar 5 dorsal root ganglion large cell AHP duration (ms) 2.8 ± 0.19 (36) 2.8 (ms) Data Table