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Article: Role of gap junctions in synchronized neuronal oscillations in the inferior olive.

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Leznik E; Llinás R
J. Neurophysiol., 2005



TABLE 1.Effects of 18{beta}-GA on physiological properties of IO neurons


Control 18{beta}-GA

Number of indirectly labeled cells per Neurobiotin injection* 12.0 ± 1.1 (6) 0.2 ± 0.1 (9)
Input resistance, MΩ 33.2 ± 3.3 (8) 38.4 ± 4.0 (8)
Time constant, ms§ 8.6 ± 0.6 (8) 6.7 ± 0.6 (8)
Membrane capacitance, nF 0.27 ± 0.06 (8) 0.18 ± 0.04 (8)
Na+ spike amplitude, mV 78 ± 1.1 (29) 78 ± 1.3 (15)
LTS amplitude, mV 24.6 ± 1.0 (29) 24.9 ± 1.3 (15)
HTS amplitude, mV 59.8 ± 2.4 (29) 66.0 ± 1.7 (13)
HTS duration, ms** 3.7 ± 0.3 (29) 6.7 ± 0.5 (13)
Oscillation frequency, Hz 6.0 ± 0.5 (31) 6.9 ± 0.4 (23)
Oscillations amplitude, mV 7.4 ± 0.7 (31) 7.1 ± 1.2 (23)

Data are shown as mean ± SE. Numbers in parentheses indicate the number of neurons tested.

* P < 0.0001 compared with control (unpaired 2-tailed Student's t-test).

P < 0.002 compared with control (paired 2-tailed Student's t-test).

Time constant was estimated using a single exponential fit of the charging current.

§ P < 0.001 compared with control (paired 2-tailed Student's t-test).

Capacitance was determined by dividing time constant by input resistance.

** P < 0.001 compared with control (unpaired 2-tailed Student's t-test). 18{beta}-GA, 18{beta}-glycyrrhetinic acid.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Inferior olive neuron input resistance 33.2 ± 3.3 (8) 33.2 (MΩ) Data Table
Inferior olive neuron membrane time constant 8.6 ± 0.6 (8) 8.6 (ms) Data Table
Inferior olive neuron cell capacitance 0.27 ± 0.06 (8) -- Data Table
Inferior olive neuron spike amplitude from resting (mV) 78.0 ± 1.1 (29) 78.0 (mV) Data Table